| SKIP001105 | |
| SKIP ID | SKIP001105 |
| Organism(En) | - |
| Organism(Ja) | - |
| Cell Type(En) | - |
| Cell Type(Ja) | - |
| Cell Tissue(En) | - |
| Cell Tissue(Ja) | - |
| Cell Origin | Diseased |
| Cell Name 1(En) | APP1E111 |
| Cell Name 1(Ja) | APP1E111 |
| Cell Name 2(En) | - |
| Cell Name 2(Ja) | - |
| Disease Name 1(Ja) | 家族性アルツハイマー病 |
| ICD Code 1 | G309 |
| Disease Name 1(En) | Alzheimer's disease |
| OMIM1 | F693 |
| Disease Name 2(Ja) | - |
| ICD Code 2 | - |
| Disease Name 2(En) | - |
| OMIM 2 | - |
| Disease Name 3(Ja) | - |
| ICD Code 3 | - |
| Disease Name 3(En) | - |
| OMIM 3 | - |
| Age | - |
| Age Range | -- |
| Sex | -- |
| Race(En) | - |
| Race(Ja) | - |
| Genetic Diagnosis | Yes |
| Not Detected | No |
| Description(En) | Disease specific iPS cells from a patient of Alzheimer's disease. |
| Description(Ja) | 疾患特異的iPS細胞株。APP-E693Δ変異家族性アルツハイマー病患者由来。 |
| Cell Morphology | human ES-like |
| Grade | Research Grade |
| Vector | Plasmid |
| Transgene | Human complementary DNAs for reprogramming factors were transduced in HDFs with episomal vectors (SOX2, KLF4, OCT4, L-MYC, LIN28, and small hairpin RNA for p53). |
| Adhesiveness | - |
| Feeder | Yes |
| Feeder Cell | SNL |
| Medium | Primate ES cell medium (ReproCELL Inc. Japan) with 4 ng/ml basic FGF (Wako Pure Chemicals Industries, Ltd, Japan) |
| Genome Editing | - |
| CO2 | - |
| Mycoplasma | - |
| Detection of Contaminants Mycoplasma | - |
| Pluripotent Markers | Yes |
| Pluripotent Markers Assay | - |
| in vitro Differentiation | Yes |
| in vitro Differentiation Assay | - |
| in vivo Differentiation | Yes |
| in vivo Differentiation Assay | Teratoma formation |
| Other 1 Assay | Yes |
| Other 1 Assay Method | Bisulfite genomic sequencing |
| Other 2 Assay | - |
| Other 2 Assay Method | - |
| Other 3 Assay | - |
| Other 3 Assay Method | - |
| Karyotype | Yes |
| Karyotype Assay | - |
| Remaining Vector Detection | - |
| Remaining Vector Detection Assay | - |
| STR | - |
| HLA | - |
| Stem Cell Transcriptome analysis | - |
| Stem Cell Transcriptome analysis Assay | - |
| Author Name(En) | Takayuki Kondo |
| Author Name(Ja) | 近藤孝之 |
| Author Organization(En) | Center for iPS Cell Research and Application (CiRA), Kyoto University |
| Author Organization(Ja) | 京都大学iPS細胞研究所 |
| Author Contact Email | - |
| PI Organization(En) | Center for iPS Cell Research and Application (CiRA), Kyoto University |
| PI Organization(Ja) | 京都大学iPS細胞研究所 |
| PI Name(En) | Haruhisa Inoue |
| PI Name(Ja) | 井上治久 |
| PI Contact Email | haruhisa[at]cira[dot]kyoto-u[dot]ac[dot]jp |
| Availability | Information Only |
| Provider Organization(En) | Center for iPS Cell Research and Application (CiRA), Kyoto University |
| Provider Organization(Ja) | 京都大学iPS細胞研究所 |
| Provider Email | - |
| Provider URL | http://www.cira.kyoto-u.ac.jp/ |
| Ethical Statement(En) | - |
| Ethical Statement(Ja) | - |
| Terms of Use(En) | - |
| Terms of Use(Ja) | - |
| PubMed ID | 23434393 |
| DOI | 10.1016/j.stem.2013.01.009 |
| Title | Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. |
| Authors | Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H |
| Journal | Cell Stem Cell |
| Year | 2013 |
| Volume | 12 |
| Issue | 4 |
| Pages | 487-96 |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/23434393 |
| Free input | - |
| Note | - |