1700
Entry 1700
Residue(mutation) V345C
Residue -
Functionally important yes
Function of the protein drug transport; inter-domain communication
Location TM6
Protein Name(abbreviation) Multidrug transporter, P-glycoprotein
Source(scientific name) Homo sapiens
Source(english name) Human
Authors Storm J, O'Mara ML, Crowley EH, Peall J, Tieleman DP, Kerr ID, Callaghan R
Journal Reference Biochemistry. 2007 Sep 4;46(35):9899-910
PMID 17696319
Experiments Calorimetric assay
Experimental data 9.3
Parameter EC50 (microM)
Methods/conditions Vinblastine
PDB ID -
ASA -
Sec. Str -
Uniprot ID MDR1_HUMAN (P08183)
Type Helix
Remarks -
Keywords inter-domain communication; drug transport; substrate translocation; ATPase activity