1704 |
Entry |
1704 |
Residue(mutation) |
- |
Residue |
Wild |
Functionally important |
yes |
Function of the protein |
drug transport; inter-domain communication |
Location |
- |
Protein Name(abbreviation) |
Multidrug transporter, P-glycoprotein |
Source(scientific name) |
Homo sapiens |
Source(english name) |
Human |
Authors |
Storm J, O'Mara ML, Crowley EH, Peall J, Tieleman DP, Kerr ID, Callaghan R |
Journal Reference |
Biochemistry. 2007 Sep 4;46(35):9899-910 |
PMID |
17696319 |
Experiments |
Calorimetric assay |
Experimental data |
2.4 |
Parameter |
fold stimulation |
Methods/conditions |
Vinblastine |
PDB ID |
- |
ASA |
- |
Sec. Str |
- |
Uniprot ID |
MDR1_HUMAN (P08183) |
Type |
Helix |
Remarks |
- |
Keywords |
inter-domain communication; drug transport; substrate translocation; ATPase activity |