1831
Entry 1831
Residue(mutation) R252C;A489C
Residue -
Functionally important yes
Function of the protein Receptor-G protein coupling
Location TM5;TM6
Protein Name(abbreviation) M3 muscarinic acetylcholine receptor
Source(scientific name) Rattus norvegicus
Source(english name) Rat
Authors Li JH, Hamdan FF, Kim SK, Jacobson KA, Zhang X, Han SJ, Wess J.
Journal Reference Biochemistry. 2008 Mar 4;47(9):2776-88.
PMID 18247581
Experiments site directed mutagenesis; Disulfide cross-linking
Experimental data 82
Parameter Basal IP (%)
Methods/conditions Carbachol-induced IP production
PDB ID 2CSA
ASA -
Sec. Str -
Uniprot ID ACM3_RAT (P08483)
Type Helix
Remarks -
Keywords conformational change; disulfide cross linking; GPCR; Cys mutant