1833 |
Entry |
1833 |
Residue(mutation) |
R252C;T491C |
Residue |
- |
Functionally important |
yes |
Function of the protein |
Receptor-G protein coupling |
Location |
TM5;TM6 |
Protein Name(abbreviation) |
M3 muscarinic acetylcholine receptor |
Source(scientific name) |
Rattus norvegicus |
Source(english name) |
Rat |
Authors |
Li JH, Hamdan FF, Kim SK, Jacobson KA, Zhang X, Han SJ, Wess J. |
Journal Reference |
Biochemistry. 2008 Mar 4;47(9):2776-88. |
PMID |
18247581 |
Experiments |
site directed mutagenesis; Disulfide cross-linking |
Experimental data |
108 |
Parameter |
Basal IP (%) |
Methods/conditions |
Carbachol-induced IP production |
PDB ID |
2CSA |
ASA |
- |
Sec. Str |
- |
Uniprot ID |
ACM3_RAT (P08483) |
Type |
Helix |
Remarks |
- |
Keywords |
conformational change; disulfide cross linking; GPCR; Cys mutant |