2456
Entry 2456
Residue(mutation) W586A
Residue -
Functionally important -
Function of the protein cell swelling; channel activation
Location TM3
Protein Name(abbreviation) Cation channel TRPV4
Source(scientific name) Homo sapiens
Source(english name) Human
Authors Vriens J, Owsianik G, Janssens A, Voets T, Nilius B
Journal Reference J Biol Chem. 2007 Apr 27;282(17):12796-803
PMID 17341586
Experiments Electrophysiology
Experimental data 16
Parameter EC50 (microM)
Methods/conditions dI: -80mV
PDB ID -
ASA -
Sec. Str -
Uniprot ID TRPV4_HUMAN (Q9HBA0)
Type Helix
Remarks -
Keywords transmembrane segment; activation; binding site