2456 |
Entry |
2456 |
Residue(mutation) |
W586A |
Residue |
- |
Functionally important |
- |
Function of the protein |
cell swelling; channel activation |
Location |
TM3 |
Protein Name(abbreviation) |
Cation channel TRPV4 |
Source(scientific name) |
Homo sapiens |
Source(english name) |
Human |
Authors |
Vriens J, Owsianik G, Janssens A, Voets T, Nilius B |
Journal Reference |
J Biol Chem. 2007 Apr 27;282(17):12796-803 |
PMID |
17341586 |
Experiments |
Electrophysiology |
Experimental data |
16 |
Parameter |
EC50 (microM) |
Methods/conditions |
dI: -80mV |
PDB ID |
- |
ASA |
- |
Sec. Str |
- |
Uniprot ID |
TRPV4_HUMAN (Q9HBA0) |
Type |
Helix |
Remarks |
- |
Keywords |
transmembrane segment; activation; binding site |