411 |
Entry |
411 |
Residue(mutation) |
V384G;G391D |
Residue |
- |
Functionally important |
yes |
Function of the protein |
LACTOSE UPTAKE (non toxic, reduced activity) |
Location |
TM 12; |
Protein Name(abbreviation) |
Lactose permease |
Source(scientific name) |
Escherichia coli |
Source(english name) |
- |
Authors |
Stewart C, Bailey J, Manoil C. |
Journal Reference |
J Biol Chem. 1998 Oct 23;273(43):28078-84 |
PMID |
9774425 |
Experiments |
cassette mutagenesis |
Experimental data |
10% |
Parameter |
[C14 lactose uptake] (%) |
Methods/conditions |
lactose uptake assay |
PDB ID |
1PV6 |
ASA |
- |
Sec. Str |
- |
Uniprot ID |
LACY_ECOLI (P02920) |
Type |
Helix |
Remarks |
- |
Keywords |
transport function; toxic; membrane protein folding; disease |