416
Entry 416
Residue(mutation) I395K;S396A
Residue -
Functionally important yes
Function of the protein LACTOSE UPTAKE (non toxic, reduced activity)
Location TM 12;
Protein Name(abbreviation) Lactose permease
Source(scientific name) Escherichia coli
Source(english name) -
Authors Stewart C, Bailey J, Manoil C.
Journal Reference J Biol Chem. 1998 Oct 23;273(43):28078-84
PMID 9774425
Experiments cassette mutagenesis
Experimental data 12%
Parameter [C14 lactose uptake] (%)
Methods/conditions lactose uptake assay
PDB ID 1PV6
ASA -
Sec. Str -
Uniprot ID LACY_ECOLI (P02920)
Type Helix
Remarks -
Keywords transport function; toxic; membrane protein folding; disease