| H00016 | |
| H番号 | H00016 |
| 名称 | 口腔癌 |
| 概要 | Oral cancer refers to a subgroup of head and neck malignancies that develop at the lips, tongue, salivary glands, gingiva, floor of the mouth, oropharynx, buccal surfaces and other intra-oral locations, according to the International Classification of Diseases. Nevertheless, the term is synonymous to squamous cell carcinoma (SCC) of oral mucosal origin that accounts for more than 90% of all malignant presentations at the aforementioned anatomical sites. Worldwide, oral SCC (OSCC) is the sixth most common cancer; more than 300,000 new cases are diagnosed each year. The development of OSCC is a multistep process requiring the accumulation of multiple genetic alterations, influenced by a patient's genetic predisposition as well as by environmental influences, including tobacco, alcohol, chronic inflammation, and viral infection. The genetic changes include activation of the epidermal growth factor receptor (EGFR), alterations of tumor suppressors p53 and p16, and cyclin D1 overexpression. |
| カテゴリ | がん |
| ネットワーク | - |
| 病因遺伝子 | p53 (mutation, deletion) [HSA:7157] [KO:K04451] p16/INK4A (mutation, loss of expression) [HSA:1029] [KO:K06621] EGFR (overexpression) [HSA:1956] [KO:K04361] c-myc/N-myc (amplification, overexpression) [HSA:4609] [KO:K04377] N-ras (amplification) [HSA:4893] [KO:K07828] K-ras (amplification) [HSA:3845] [KO:K07827] Cyclin D1 (amplification) [HSA:595] [KO:K04503] STAT-3 (expression) [HSA:6774] [KO:K04692] |
| 病原体 | Human papillomavirus type 16 [GN:T40087] Human papillomavirus type 18 [GN:T40088] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | ブレオマイシン塩酸塩 [DR:D03229] ペプロマイシン硫酸塩 [DR:D02063] ストレプトコックス・ピオゲネス（A群3型）Su株ペニシリン処理凍結乾燥粉末 [DR:D08756] |
| コメント | - |
| リンク | ICD-11: 2B60 2B61 2B62 2B63 2B64 2B65 2B66 ICD-10: C00 C01 C02 C03 C04 C05 C06 MeSH: D009062 |
| 文献 | PMID:17258495 著者 Tsantoulis PK, Kastrinakis NG, Tourvas AD, Laskaris G, Gorgoulis VG タイトル Advances in the biology of oral cancer. 雑誌 Oral Oncol 43:523-34 (2007) DOI:10.1016/j.oraloncology.2006.11.010 PMID:18096889 著者 Choi S, Myers JN タイトル Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. 雑誌 J Dent Res 87:14-32 (2008) DOI:10.1177/154405910808700104 PMID:12444391 著者 Das BR, Nagpal JK. タイトル Understanding the biology of oral cancer. 雑誌 Med Sci Monit 8:RA258-67 (2002) PMID:17530489 著者 Abnet CC. タイトル Carcinogenic food contaminants. 雑誌 Cancer Invest 25:189-96 (2007) DOI:10.1080/07357900701208733 PMID:17646865 著者 Seitz HK, Stickel F. タイトル Molecular mechanisms of alcohol-mediated carcinogenesis. 雑誌 Nat Rev Cancer 7:599-612 (2007) DOI:10.1038/nrc2191 PMID:9448210 著者 Norton SA. タイトル Betel: consumption and consequences. 雑誌 J Am Acad Dermatol 38:81-8 (1998) DOI:10.1016/S0190-9622(98)70543-2 PMID:17163423 著者 Thomas SJ, Bain CJ, Battistutta D, Ness AR, Paissat D, Maclennan R. タイトル Betel quid not containing tobacco and oral cancer: a report on a case-control study in Papua New Guinea and a meta-analysis of current evidence. 雑誌 Int J Cancer 120:1318-23 (2007) DOI:10.1002/ijc.22304 PMID:14996286 著者 Warnakulasuriya S. タイトル Smokeless tobacco and oral cancer. 雑誌 Oral Dis 10:1-4 (2004) DOI:10.1046/j.1354-523X.2003.00975.x PMID:9524432 著者 Hoffmann D, Djordjevic MV. タイトル Chemical composition and carcinogenicity of smokeless tobacco. 雑誌 Adv Dent Res 11:322-9 (1997) DOI:10.1177/08959374970110030301 PMID:15489140 著者 Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. タイトル Environmental and chemical carcinogenesis. 雑誌 Semin Cancer Biol 14:473-86 (2004) DOI:10.1016/j.semcancer.2004.06.010 PMID:15552776 著者 Sasco AJ, Secretan MB, Straif K. タイトル Tobacco smoking and cancer: a brief review of recent epidemiological evidence. 雑誌 Lung Cancer 45 Suppl 2:S3-9 (2004) DOI:10.1016/j.lungcan.2004.07.998 PMID:12767868 著者 Schliephake H. タイトル Prognostic relevance of molecular markers of oral cancer--a review. 雑誌 Int J Oral Maxillofac Surg 32:233-45 (2003) DOI:10.1054/ijom.2002.0383 PMID:14693233 著者 Bettendorf O, Piffko J, Bankfalvi A. タイトル Prognostic and predictive factors in oral squamous cell cancer: important tools for planning individual therapy? 雑誌 Oral Oncol 40:110-9 (2004) DOI:10.1016/j.oraloncology.2003.08.010 PMID:15580114 著者 Chimenos-Kustner E, Font-Costa I, Lopez-Lopez J. タイトル Oral cancer risk and molecular markers. 雑誌 Med Oral Patol Oral Cir Bucal 9:381-4; 377-80 (2004) |