| H00017 | |
| H番号 | H00017 |
| 名称 | 食道癌 |
| 概要 | Esophageal cancer represents the 9th leading cancer in the world and is associated with a 5-year survival rate under 25%. The two main forms are squamous-cell carcinoma (ESCC) and adenocarcinoma (EAC). ESCC is the most frequent histological subtype in esophageal cancer, although the incidence of EAC is increasing faster than any other malignancy in the western world. Whereas ESCC can be attributed to alcohol and tobacco consumption, the most important risk factor for the development of EAC is duodenal-gastric-esophageal reflux. In the process of tumorigenesis at the cellular level, multiple genetic alterations are involved, including mutation of the p53 gene, amplification of cyclin D1 gene, among others. |
| カテゴリ | がん |
| ネットワーク | - |
| 病因遺伝子 | EGFR (overexpression) [HSA:1956] [KO:K04361] PTGS2 (overexpression) [HSA:5743] [KO:K11987] NOS2 (increased expression) [HSA:4843] [KO:K13241] FAS (increased expression) [HSA:355] [KO:K04390] CCND1 (amplification) [HSA:595] [KO:K04503] TP53 [HSA:7157] [KO:K04451] CDKN2A [HSA:1029] [KO:K06621] RB1 [HSA:5925] [KO:K06618] APC [HSA:324] [KO:K02085] DCC [HSA:1630] [KO:K06765] LZTS1 [HSA:11178] [KO:K26460] RNF6 [HSA:6049] [KO:K22753] TGFBR2 [HSA:7048] [KO:K04388] WWOX [HSA:51741] [KO:K19329] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | フルオロウラシル [DR:D00584] ブレオマイシン塩酸塩 [DR:D03229] ビンデシン硫酸塩 [DR:D01769] パクリタキセル [DR:D00491] ドセタキセル水和物 [DR:D02165] ドセタキセル [DR:D07866] ニボルマブ [DR:D10316] ペムブロリズマブ [DR:D10574] イピリムマブ [DR:D04603] シスプラチン [DR:D00275] ネダプラチン [DR:D01416] タラポルフィンナトリウム [DR:D01985] |
| コメント | - |
| リンク | ICD-11: 2B70 ICD-10: C15 MeSH: D004938 OMIM: 133239 |
| 文献 | PMID:15622457 (EGFR, TP53, PTGS2, NOS2, CCND1, CDKN2A, RB1) 著者 Kuwano H, Kato H, Miyazaki T, Fukuchi M, Masuda N, Nakajima M, Fukai Y, Sohda M, Kimura H, Faried A. タイトル Genetic alterations in esophageal cancer. 雑誌 Surg Today 35:7-18 (2005) DOI:10.1007/s00595-004-2885-3 PMID:12951586 (APC, CDKN2A, NOS2, RB1, PTGS2, TP53, RB1, EGFR, FAS) 著者 Wild CP, Hardie LJ. タイトル Reflux, Barrett's oesophagus and adenocarcinoma: burning questions. 雑誌 Nat Rev Cancer 3:676-84 (2003) DOI:10.1038/nrc1166 PMID:15914317 (CCND1, TP53, RB1, CDKN2A, APC, WWOX, FAS) 著者 McCabe ML, Dlamini Z. タイトル The molecular mechanisms of oesophageal cancer. 雑誌 Int Immunopharmacol 5:1113-30 (2005) DOI:10.1016/j.intimp.2004.11.017 PMID:8187090 (DCC) 著者 Miyake S, Nagai K, Yoshino K, Oto M, Endo M, Yuasa Y タイトル Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. 雑誌 Cancer Res 54:3007-10 (1994) PMID:11504921 (LZTS1) 著者 Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM タイトル FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis. 雑誌 Proc Natl Acad Sci U S A 98:10374-9 (2001) DOI:10.1073/pnas.181222898 PMID:12154016 (RNF6) 著者 Lo HS, Hu N, Gere S, Lu N, Su H, Goldstein AM, Taylor PR, Lee MP タイトル Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma. 雑誌 Cancer Res 62:4191-3 (2002) PMID:10789724 (TGFBR2) 著者 Tanaka S, Mori M, Mafune K, Ohno S, Sugimachi K タイトル A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. 雑誌 Br J Cancer 82:1557-60 (2000) DOI:10.1054/bjoc.1999.1178 PMID:11956080 (WWOX) 著者 Kuroki T, Trapasso F, Shiraishi T, Alder H, Mimori K, Mori M, Croce CM タイトル Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma. 雑誌 Cancer Res 62:2258-60 (2002) |