| H00026 | |
| H番号 | H00026 |
| 名称 | 子宮内膜癌 |
| 概要 | Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification. |
| カテゴリ | がん 疾患パスウェイ hsa05213 子宮内膜癌 |
| ネットワーク | nt06271 Endometrial cancer |
| 病因遺伝子 | ERBB2 (amplification) [HSA:2064] [KO:K05083] PTEN (mutation, deletions, methylation) [HSA:5728] [KO:K01110] MLH1 (mutation, methylation) [HSA:4292] [KO:K08734] KRAS [HSA:3845] [KO:K07827] CTNNB1 [HSA:1499] [KO:K02105] TP53 [HSA:7157] [KO:K04451] MSH3 [HSA:4437] [KO:K08736] CDH1 [HSA:999] [KO:K05689] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | マイトマイシンC [DR:D00208] メドロキシプロゲステロン酢酸エステル [DR:D00951] シクロホスファミド水和物 [DR:D00287] フルオロウラシル [DR:D00584] シタラビン [DR:D00168] ドキソルビシン塩酸塩 [DR:D01275] ピラルビシン塩酸塩 [DR:D08386] パクリタキセル [DR:D00491] ドセタキセル水和物 [DR:D02165] ドセタキセル [DR:D07866] レンバチニブメシル酸塩 [DR:D09920] ペムブロリズマブ [DR:D10574] シスプラチン [DR:D00275] |
| コメント | - |
| リンク | ICD-11: 2C76 ICD-10: C54 MeSH: D016889 OMIM: 608089 |
| 文献 | PMID:17028294 著者 Hecht JL, Mutter GL. タイトル Molecular and pathologic aspects of endometrial carcinogenesis. 雑誌 J Clin Oncol 24:4783-91 (2006) DOI:10.1200/JCO.2006.06.7173 PMID:15947972 著者 Ryan AJ, Susil B, Jobling TW, Oehler MK. タイトル Endometrial cancer. 雑誌 Cell Tissue Res 322:53-61 (2005) DOI:10.1007/s00441-005-1109-5 PMID:12583434 著者 Salvesen HB, Akslen LA. タイトル Molecular pathogenesis and prognostic factors in endometrial carcinoma. 雑誌 APMIS 110:673-89 (2002) DOI:10.1034/j.1600-0463.2002.1101001.x PMID:16508724 著者 Shiozawa T, Konishi I. タイトル Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment. 雑誌 Int J Clin Oncol 11:13-21 (2006) DOI:10.1007/s10147-005-0546-1 PMID:8782829 (MSH3) 著者 Risinger JI, Umar A, Boyd J, Berchuck A, Kunkel TA, Barrett JC タイトル Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. 雑誌 Nat Genet 14:102-5 (1996) DOI:10.1038/ng0996-102 PMID:8075649 (CDH1) 著者 Risinger JI, Berchuck A, Kohler MF, Boyd J タイトル Mutations of the E-cadherin gene in human gynecologic cancers. 雑誌 Nat Genet 7:98-102 (1994) DOI:10.1038/ng0594-98 |