| H00030 | |
| H番号 | H00030 |
| 名称 | 子宮頸癌 |
| 概要 | Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus (HPV) types, particularly types 16, 18, 33 and 42. Experimental studies show that the E6 and E7 genes of these high risk HPVs are oncogenes that deregulate key cell cycle controls. The E6 and E7 oncoproteins bind respectively to the p53 and Retinoblastoma (Rb) tumor suppressor proteins, which are involved in the regulation of growth control. The abnormalities in other cellular genes found in cervical cancer, including mutations in ras family of genes, and amplification in EGFR and ERBB2, may also play an important role in carcinogenesis and the aggressiveness of cervical tumors, although to date the role of most of these genetic abnormalities does not appear to be as important as the role of HPV. |
| カテゴリ | がん |
| ネットワーク | nt06110(H00030) MAPK signaling (viruses and bacteria) nt06114(H00030) PI3K signaling (viruses) nt06122(H00030) IFN signaling (viruses) nt06123(H00030) TNF signaling (viruses and bacteria) nt06129(H00030) MHC presentation (viruses) nt06130(H00030) Cell cycle (viruses) nt06131(H00030) Apoptosis (viruses and bacteria) nt06135(H00030) Cytoskeletal regulation (viruses and bacteria) nt06140(H00030) Transcription (viruses) nt06166 Human papillomavirus (HPV) nt06511(H00030) NOTCH signaling nt06516(H00030) TNF signaling nt06517(H00030) TLR signaling nt06522(H00030) mTOR signaling nt06524(H00030) Apoptosis nt06526(H00030) MAPK signaling nt06530(H00030) PI3K signaling |
| 病因遺伝子 | K-ras (mutation) [HSA:3845] [KO:K07827] H-ras (mutation) [HSA:3265] [KO:K02833] EGFR (amplification) [HSA:1956] [KO:K04361] ERBB2 (amplification) [HSA:2064] [KO:K05083] p21 (overexpression) [HSA:1026] [KO:K06625] CDK4 (overexpression) [HSA:1019] [KO:K02089] Bcl-2 (overexpression) [HSA:596] [KO:K02161] |
| 病原体 | Human papillomavirus type 16 [GN:T40087] Human papillomavirus type 18 [GN:T40088] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | マイトマイシンC [DR:D00208] シクロホスファミド水和物 [DR:D00287] イホスファミド [DR:D00343] フルオロウラシル [DR:D00584] ドキシフルリジン [DR:D01309] シタラビン [DR:D00168] テガフール・ウラシル [DR:D02131] ブレオマイシン塩酸塩 [DR:D03229] ピラルビシン塩酸塩 [DR:D08386] エトポシド [DR:D00125] パクリタキセル [DR:D00491] ノギテカン塩酸塩 [DR:D02168] イリノテカン塩酸塩水和物 [DR:D01061] ペムブロリズマブ [DR:D10574] セミプリマブ [DR:D11108] ベバシズマブ [DR:D06409] シスプラチン [DR:D00275] カルボプラチン [DR:D01363] ネダプラチン [DR:D01416] 組換え沈降4価ヒトパピローマウイルス様粒子ワクチン [DR:D10192] 組換え沈降2価ヒトパピローマウイルス様粒子ワクチン [DR:D10212] 組換え沈降9価ヒトバピローマウイルス様粒子ワクチン [DR:D11863] |
| コメント | - |
| リンク | ICD-11: 2C77 ICD-10: C53 MeSH: D002583 |
| 文献 | PMID:11486705 著者 Wolf JK, Ramirez PT. タイトル The molecular biology of cervical cancer. 雑誌 Cancer Invest 19:621-9 (2001) DOI:10.1081/CNV-100104290 PMID:10471054 著者 Lazo PA. タイトル The molecular genetics of cervical carcinoma. 雑誌 Br J Cancer 80:2008-18 (1999) DOI:10.1038/sj.bjc.6690635 PMID:16062089 著者 Patel P, Moazzam N, Potti A, Mehdi SA. タイトル Azathioprine induced hodgkin lymphoma: a case report and review of literature. 雑誌 Am J Clin Oncol 28:427-8 (2005) DOI:10.1097/01.coc.0000168670.28659.8d PMID:15168959 著者 Schrager S, Potter BE. タイトル Diethylstilbestrol exposure. 雑誌 Am Fam Physician 69:2395-400 (2004) PMID:17390375 著者 Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN. タイトル Cancer risk in women prenatally exposed to diethylstilbestrol. 雑誌 Int J Cancer 121:356-60 (2007) DOI:10.1002/ijc.22631 PMID:11281434 著者 Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK. タイトル Human papillomavirus infections: epidemiology, pathogenesis, and therapy. 雑誌 J Cutan Med Surg 5:43-60 (2001) DOI:10.1177/120347540100500110 PMID:15489140 著者 Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. タイトル Environmental and chemical carcinogenesis. 雑誌 Semin Cancer Biol 14:473-86 (2004) DOI:10.1016/j.semcancer.2004.06.010 PMID:15552776 著者 Sasco AJ, Secretan MB, Straif K. タイトル Tobacco smoking and cancer: a brief review of recent epidemiological evidence. 雑誌 Lung Cancer 45 Suppl 2:S3-9 (2004) DOI:10.1016/j.lungcan.2004.07.998 PMID:12612656 著者 Baldwin P, Laskey R, Coleman N. タイトル Translational approaches to improving cervical screening. 雑誌 Nat Rev Cancer 3:217-26 (2003) DOI:10.1038/nrc1010 PMID:12797857 著者 Garland SM. タイトル Can we really beat cervical cancer? 雑誌 Med J Aust 178:647-9 (2003) DOI:10.5694/j.1326-5377.2003.tb05396.x PMID:14739059 著者 Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR. タイトル Serum tumor markers in the management of ovarian, endometrial and cervical cancer. 雑誌 Biomed Pharmacother 58:24-38 (2004) DOI:10.1016/j.biopha.2003.11.003 |