| H00044 | |
| H番号 | H00044 |
| 名称 | 肛門管癌 |
| 概要 | Squamous cell carcinoma of the anal canal accounts for 1.5 per cent of all digestive system cancers in the USA, with an estimated 4,660 new cases and 660 deaths in 2006. Epidemiological and molecular-biology studies have now shown that sexually transmitted infection with human papillomavirus (HPV) is the most important aetiological agent. Human immunodeficiency virus (HIV) infection is also associated with anal cancer. HPV infection is transient in most immunocompetent individuals, but HIV-positive patients have evidence of persistent HPV infection within the anal canal. Current data suggest that mutations in p53, DCC and APC tumor suppressor genes contribute to the stepwise progression of anal squamous cell carcinoma in immunocompetent individuals. |
| カテゴリ | がん |
| ネットワーク | - |
| 病因遺伝子 | p53 (mutation) [HSA:7157] [KO:K04451] DCC (mutation) [HSA:1630] [KO:K06765] APC (mutation) [HSA:324] [KO:K02085] |
| 病原体 | Human papillomavirus type 16 [GN:T40087] Human papillomavirus type 18 [GN:T40088] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | 組換え沈降4価ヒトパピローマウイルス様粒子ワクチン [DR:D10192] |
| コメント | - |
| リンク | ICD-11: 2C00 ICD-10: C21 MeSH: D001005 |
| 文献 | PMID:16607677 著者 Gervaz P, Hirschel B, Morel P. タイトル Molecular biology of squamous cell carcinoma of the anus. 雑誌 Br J Surg 93:531-8 (2006) DOI:10.1002/bjs.5376 PMID:12947531 著者 Gervaz P, Allal AS, Villiger P, Buhler L, Morel P. タイトル Squamous cell carcinoma of the anus: another sexually transmitted disease. 雑誌 Swiss Med Wkly 133:353-9 (2003) PMID:11281434 著者 Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK. タイトル Human papillomavirus infections: epidemiology, pathogenesis, and therapy. 雑誌 J Cutan Med Surg 5:43-60 (2001) DOI:10.1177/120347540100500110 PMID:1311142 著者 Daling JR, Sherman KJ, Hislop TG, Maden C, Mandelson MT, Beckmann AM, Weiss NS. タイトル Cigarette smoking and the risk of anogenital cancer. 雑誌 Am J Epidemiol 135:180-9 (1992) DOI:10.1093/oxfordjournals.aje.a116270 PMID:17255774 著者 Owens SR, Greenson JK. タイトル Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas. 雑誌 Am J Surg Pathol 31:285-90 (2007) DOI:10.1097/01.pas.0000213362.10756.d3 PMID:9372374 著者 Indinnimeo M, Reale MG, Cicchini C, Stazi A, Fiori E, Izzo P. タイトル CEA, TPA, CA 19-9, SCC and CYFRA at diagnosis and in the follow-up of anal canal tumors. 雑誌 Int Surg 82:275-9 (1997) |