| H00083 | |
| H番号 | H00083 |
| 名称 | 同種移植片拒絶反応 |
| 概要 | Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nonetheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft. |
| カテゴリ | 免疫系疾患 疾患パスウェイ hsa05330 同種移植片拒絶反応 |
| ネットワーク | - |
| 病因遺伝子 | TNF [HSA:7124] [KO:K03156] IL10 [HSA:3586] [KO:K05443] TGFB1 [HSA:7040] [KO:K13375] TGFB2 [HSA:7042] [KO:K13376] TGFB3 [HSA:7043] [KO:K13377] IFNG [HSA:3458] [KO:K04687] HLA-DMA [HSA:3108] [KO:K06752] ICAM1 [HSA:3383] [KO:K06490] CTLA4 [HSA:1493] [KO:K06538] ACE [HSA:1636] [KO:K01283] ITGB3 [HSA:3690] [KO:K06493] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | タクロリムス水和物 [DR:D00107] シクロスポリン [DR:D00184] エベロリムス [DR:D02714] ミコフェノール酸モフェチル [DR:D00752] グスペリムス塩酸塩 [DR:D01566] アザチオプリン [DR:D00238] 抗ヒト胸腺細胞ウサギ免疫グロブリン [DR:D09190] バシリキシマブ [DR:D03058] |
| コメント | - |
| リンク | ICD-11: NE84 ICD-10: T86 |
| 文献 | PMID:11544006 (TNF, IL10, TGFB, IFNG, HLA-DMA, ICAM1, CTLA4, ACE, ATGB3) 著者 Akalin E, Murphy B. タイトル Gene polymorphisms and transplantation. 雑誌 Curr Opin Immunol 13:572-6 (2001) DOI:10.1016/S0952-7915(00)00261-2 PMID:15690532 著者 Warle MC, Metselaar HJ, Hop WC, Tilanus HW. タイトル Cytokine gene polymorphisms and acute liver graft rejection: a meta-analysis. 雑誌 Liver Transpl 11:19-26 (2005) DOI:10.1002/lt.20316 PMID:12089714 著者 Warle MC, Farhan A, Metselaar HJ, Hop WC, Perrey C, Zondervan PE, Kap M, de Rave S, Kwekkeboom J, Ijzermans JN, Tilanus HW, Pravica V, Hutchinson IV, Bouma GJ. タイトル Cytokine gene polymorphisms and acute human liver graft rejection. 雑誌 Liver Transpl 8:603-11 (2002) DOI:10.1053/jlts.2002.33967 PMID:15848524 著者 Lacha J, Hribova P, Kotsch K, Brabcova I, Bartosova K, Volk HD, Vitko S. タイトル Effect of cytokines and chemokines (TGF-beta, TNF-alpha, IL-6, IL-10, MCP-1, RANTES) gene polymorphisms in kidney recipients on posttransplantation outcome: influence of donor-recipient match. 雑誌 Transplant Proc 37:764-6 (2005) DOI:10.1016/j.transproceed.2004.12.224 |