| H00084 | |
| H番号 | H00084 |
| 名称 | 移植片対宿主病 |
| 概要 | Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells. GVHD pathophysiology can be summerized in a three-step process. Step 1 involves the development of an inflammatory milieu resulting from damage in the host tissues induced by the preparative chemotherapy or radiotherapy regimen. Damaged tissues secrete inflammatory cytokines, including interleukin 1 (IL-1), and tumor necrosis factor (TNF-alpha ). During step 2, antigen-presenting cells (APCs) trigger the activation of donor-derived T cells, which induce further T-cell expansion, induce cytotoxic T lymphocytes (CTL) and natural killer (NK) cells responses and prime additional mononuclear phagocytes to produce TNF-alpha and IL-1. Also, nitric oxide (NO) is produced by activated macrophages, and it may contribute to the tissue damage seen during step 3. During step 3, the effector phase, activated CTL and NK cells mediate cytotoxicity against target host cells through Fas-Fas ligand interactions and perforin-granzyme B. |
| カテゴリ | 免疫系疾患 疾患パスウェイ hsa05332 移植片対宿主病 |
| ネットワーク | - |
| 病因遺伝子 | IL10 [HSA:3586] [KO:K05443] TNF [HSA:7124] [KO:K03156] IL1A [HSA:3552] [KO:K04383] IL1RN [HSA:3557] [KO:K05481] IFNG [HSA:3458] [KO:K04687] IL6 [HSA:3569] [KO:K05405] TGFB1 [HSA:7040] [KO:K13375] TGFB2 [HSA:7042] [KO:K13376] TGFB3 [HSA:7043] [KO:K13377] IL13 [HSA:3596] [KO:K05435] TNFRSF1B [HSA:7133] [KO:K05141] IL2 [HSA:3558] [KO:K05429] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | タクロリムス水和物 [DR:D00107] シクロスポリン [DR:D00184] ルキソリチニブリン酸塩 [DR:D09960] イブルチニブ [DR:D10223] ヒト (同種) 骨髄由来間葉系幹細胞 [DR:D12587] 抗ヒト胸腺細胞ウサギ免疫グロブリン [DR:D09190] |
| コメント | - |
| リンク | ICD-11: 4B24 ICD-10: T86 MeSH: D006086 OMIM: 614395 |
| 文献 | PMID:19000150 著者 Markey KA, MacDonald KP, Hill GR タイトル Impact of cytokine gene polymorphisms on graft-vs-host disease. 雑誌 Tissue Antigens 72:507-16 (2008) DOI:10.1111/j.1399-0039.2008.01139.x PMID:12394168 著者 Holler E. タイトル Cytokines, viruses, and graft-versus-host disease. 雑誌 Curr Opin Hematol 9:479-84 (2002) DOI:10.1097/00062752-200211000-00002 PMID:18503983 著者 Dickinson AM, Holler E. タイトル Polymorphisms of cytokine and innate immunity genes and GVHD. 雑誌 Best Pract Res Clin Haematol 21:149-64 (2008) DOI:10.1016/j.beha.2008.03.004 PMID:17976248 著者 Dickinson AM, Harrold JL, Cullup H. タイトル Haematopoietic stem cell transplantation: can our genes predict clinical outcome? 雑誌 Expert Rev Mol Med 9:1-19 (2007) DOI:10.1017/S1462399407000488 PMID:15245422 著者 Gilliam AC. タイトル Update on graft versus host disease. 雑誌 J Invest Dermatol 123:251-7 (2004) DOI:10.1111/j.1523-1747.2004.23211.x PMID:14657427 (IL10) 著者 Lin MT, Storer B, Martin PJ, Tseng LH, Gooley T, Chen PJ, Hansen JA タイトル Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. 雑誌 N Engl J Med 349:2201-10 (2003) DOI:10.1056/NEJMoa022060 |