| H00295 | |
| H番号 | H00295 |
| 名称 | ウイルス性心筋炎 |
| 概要 | Myocarditis is clinically defined as cardiac disease associated with inflammation of the myocardium and necrosis and/or degeneration of adjacent myocytes in the absence of an ischemic event. Most often, myocarditis results from common viral infections; less commonly, specific forms of myocarditis may result from other pathogens, toxic or hypersensitivity drug reactions, giant-cell myocarditis, or sarcoidosis. More than 20 common viruses, including coxsackieviruses, adenoviruses, influenza viruses, cytomegaloviruses, and human immunodeficiency virus, have been associated with myocarditis in humans. However, coxsackieviruses are considered the dominant cause of myocarditis, particularly in neonates and young children. After the acute phase caused by direct cytopathic effects of the virus, a small proportion of patients subsequently develop autoimmune- mediated, chronic myocarditis, accompanied by circulating autoantibodies to cardiac myosin and other heart antigens, which can sometimes lead to heart failure and death associated with dilated cardiomyopathy (DCM). Genetic linkage between susceptibility to myocarditis/DCM and the major histocompatibility complex (MHC) genes has been reported in both humans and experimentally induced mouse models. |
| カテゴリ | 循環器系疾患 疾患パスウェイ hsa05416 ウイルス性心筋炎 |
| ネットワーク | - |
| 病因遺伝子 | HLA-DQB1 (polymorphism) [HSA:3119] [KO:K06752] |
| 病原体 | Enteroviruses Adenoviruses Cytomegalovirus Parvovirus Hepatitis B and C HIV Human herpes viruses Influenza viruses |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: BC42.1 ICD-10: I40 |
| 文献 | PMID:19127454 著者 Portig I, Sandmoeller A, Kreilinger S, Maisch B タイトル HLA-DQB1* polymorphism and associations with dilated cardiomyopathy, inflammatory dilated cardiomyopathy and myocarditis. 雑誌 Autoimmunity 42:33-40 (2009) DOI:10.1080/08916930802258651 PMID:18190873 著者 Li HS, Ligons DL, Rose NR タイトル Genetic complexity of autoimmune myocarditis. 雑誌 Autoimmun Rev 7:168-73 (2008) DOI:10.1016/j.autrev.2007.11.010 PMID:8793712 著者 Fairley CK, Ryan M, Wall PG, Weinberg J タイトル The organisms reported to cause infective myocarditis and pericarditis in England and Wales. 雑誌 J Infect 32:223-5 (1996) DOI:10.1016/S0163-4453(96)80023-5 PMID:18617482 著者 Dennert R, Crijns HJ, Heymans S タイトル Acute viral myocarditis. 雑誌 Eur Heart J 29:2073-82 (2008) DOI:10.1093/eurheartj/ehn296 |