| H00370 | |
| H番号 | H00370 |
| 名称 | 進行性多巣性白質脳症 |
| 概要 | Progressive multifocal leukoencephalopathy (PML) is a fatal neurological disorder characterized by destruction of oligodendrocytes by the JC polyomavirus that occurs in immunosuppressed individuals such as patients with AIDS. Patients with PML show white matter lesions on head computed tomography scan or magnetic resonance imaging. |
| カテゴリ | ウイルス感染症 |
| ネットワーク | - |
| 病因遺伝子 | - |
| 病原体 | JC polyomavirus [GN:T40072] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | Combination therapy AIDS-associated: Highly active antiretroviral therapy (HAART) + Cidofovir Immunodepressed patient: Discontinuation of immunosuppressive agent + Cidofovir [DR:D00273] |
| リンク | ICD-11: 8A45.02 ICD-10: A81.2 MeSH: D007968 MedlinePlus: 000674 |
| 文献 | PMID:15167073 著者 Koralnik IJ タイトル New insights into progressive multifocal leukoencephalopathy. 雑誌 Curr Opin Neurol 17:365-70 (2004) DOI:10.1097/00019052-200406000-00019 PMID:7551117 著者 Major EO, Ault GS タイトル Progressive multifocal leukoencephalopathy: clinical and laboratory observations on a viral induced demyelinating disease in the immunodeficient patient. 雑誌 Curr Opin Neurol 8:184-90 (1995) |