| H01037 | |
| H番号 | H01037 |
| 名称 | 膀胱尿管逆流 |
| 概要 | Vesicoureteral reflux (VUR) is the abnormal retrograde urinary flow from the bladder to the kidney that affects approximately 1% of the general population. It is associated with an increased risk of recurrent urinary tract infection, pyelonephritis, and renal scarring. |
| カテゴリ | 泌尿器系疾患 |
| ネットワーク | - |
| 病因遺伝子 | (VUR2) ROBO2 [HSA:6092] [KO:K06754] (VUR3) SOX17 [HSA:64321] [KO:K04495] (VUR8) TNXB [HSA:7148] [KO:K06252] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: GB56.5 ICD-10: N13.7 MeSH: D014718 OMIM: 610878 613674 615963 |
| 文献 | PMID:22264440 著者 Routh JC, Bogaert GA, Kaefer M, Manzoni G, Park JM, Retik AB, Rushton HG, Snodgrass WT, Wilcox DT タイトル Vesicoureteral reflux: current trends in diagnosis, screening, and treatment. 雑誌 Eur Urol 61:773-82 (2012) DOI:10.1016/j.eururo.2012.01.002 PMID:21862976 著者 Puri P, Gosemann JH, Darlow J, Barton DE タイトル Genetics of vesicoureteral reflux. 雑誌 Nat Rev Urol 8:539-52 (2011) DOI:10.1038/nrurol.2011.113 PMID:21475075 著者 Carvas F, Silva A, Nguyen HT タイトル The genetics of primary, nonsyndromic vesicoureteral reflux. 雑誌 Curr Opin Urol 20:336-42 (2010) DOI:10.1097/MOU.0b013e328339b739 PMID:17357069 (ROBO2) 著者 Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, Kim HG, Fan Y, Xi Q, Li QG, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yan J, Giltay JC, Wijmenga C, de Jong TP, Feather SA, Woolf AS, Rao Y, Lupski JR, Eccles MR, Quade BJ, Gusella JF, Morton CC, Maas RL タイトル Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. 雑誌 Am J Hum Genet 80:616-32 (2007) DOI:10.1086/512735 PMID:20960469 (SOX17) 著者 Gimelli S, Caridi G, Beri S, McCracken K, Bocciardi R, Zordan P, Dagnino M, Fiorio P, Murer L, Benetti E, Zuffardi O, Giorda R, Wells JM, Gimelli G, Ghiggeri GM タイトル Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract. 雑誌 Hum Mutat 31:1352-9 (2010) DOI:10.1002/humu.21378 PMID:23620400 (TNXB) 著者 Gbadegesin RA, Brophy PD, Adeyemo A, Hall G, Gupta IR, Hains D, Bartkowiak B, Rabinovich CE, Chandrasekharappa S, Homstad A, Westreich K, Wu G, Liu Y, Holanda D, Clarke J, Lavin P, Selim A, Miller S, Wiener JS, Ross SS, Foreman J, Rotimi C, Winn MP タイトル TNXB mutations can cause vesicoureteral reflux. 雑誌 J Am Soc Nephrol 24:1313-22 (2013) DOI:10.1681/ASN.2012121148 |