| H01102 | |
| H番号 | H01102 |
| 名称 | 下垂体腺腫 |
| 概要 | Pituitary adenomas are an important and frequently occurring form of intracranial tumor. They are usually benign but can give rise to severe clinical syndromes due to hormonal excess, or to visual/cranial disturbances due to mass effect. The tumor can be clinically nonfunctioning or hormone secreting. Among the latter, prolactin (PRL) and growth hormone (GH)-secreting adenomas are the most common. The majority of pituitary adenomas arise sporadically, although a subset occurs as component tumors of well-characterized familial cancer syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC), and MEN1-like syndrome (MEN4). |
| カテゴリ | 新生物 |
| ネットワーク | nt06310(H01102) CRH-ACTH-cortisol signaling |
| 病因遺伝子 | (MEN1) MEN1 [HSA:4221] [KO:K14970] (MEN4) CDKN1B [HSA:1027] [KO:K06624] (CNC) PRKAR1A [HSA:5573] [KO:K04739] (PITA1) AIP [HSA:9049] [KO:K17767] (PITA2) GPR101 [HSA:83550] [KO:K08423] (PITA3) GNAS [HSA:2778] [KO:K04632] (PITA4) USP8 [HSA:9101] [KO:K11839] (PITA5) CDH23 [HSA:64072] [KO:K06813] RASD1 [HSA:51655] [KO:K07843] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | ブロモクリプチンメシル酸塩 [DR:D00780] カベルゴリン [DR:D00987] ランレオチド酢酸塩 [DR:D04666] |
| コメント | - |
| リンク | ICD-11: 2F37.0 ICD-10: D44.8 MeSH: D010911 OMIM: 600634 610755 160980 102200 300943 617686 219090 617540 |
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