| H01154 | |
| H番号 | H01154 |
| 名称 | 早期興奮症候群; WPW 症候群 |
| 概要 | Wolff-Parkinson-White (WPW) syndrome is the most common cause of ventricular pre-excitation, a condition where all or part of the ventricle is excited earlier than would normally be expected, often leading to ventricular fibrillation and sudden cardiac death. It was recently discovered that mutations in PRKAG2, that encodes a subunit of the AMP-activated protein kinase, is responsible for WPW syndrome. |
| カテゴリ | 循環器系疾患 |
| ネットワーク | - |
| 病因遺伝子 | PRKAG2 [HSA:51422] [KO:K07200] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | The use of Verapamil [DG:DG00329] or Digoxin [DR:D00298] for long-term therapy appears to be contraindicated for many patients with WPW syndrome. |
| リンク | ICD-11: BC81.4 ICD-10: I45.6 OMIM: 194200 |
| 文献 | PMID:20888928 著者 Sternick EB, Oliva A, Gerken LM, Magalhaes L, Scarpelli R, Correia FS, Rego S, Santana O, Brugada R, Wellens HJ タイトル Clinical, electrocardiographic, and electrophysiologic characteristics of patients with a fasciculoventricular pathway: the role of PRKAG2 mutation. 雑誌 Heart Rhythm 8:58-64 (2011) DOI:10.1016/j.hrthm.2010.09.081 PMID:16686673 著者 Light PE タイトル Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction? 雑誌 J Cardiovasc Electrophysiol 17 Suppl 1:S158-S161 (2006) DOI:10.1111/j.1540-8167.2006.00399.x PMID:15952923 著者 Redfearn DP, Krahn AD, Skanes AC, Yee R, Klein GJ タイトル Use of medications in Wolff-Parkinson-White syndrome. 雑誌 Expert Opin Pharmacother 6:955-63 (2005) DOI:10.1517/14656566.6.6.955 PMID:17547624 (Drug) 著者 Fragakis N, Iliadis I, Papanastasiou S, Lambrou A, Katsaris G タイトル Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome. 雑誌 Pacing Clin Electrophysiol 30:823-5 (2007) DOI:10.1111/j.1540-8159.2007.00762.x |