| H01191 | |
| H番号 | H01191 |
| 名称 | 鼻茸を伴うアスピリン喘息 |
| 概要 | Asthma is a phenotypically heterogeneous disorder with many etiologic factors and clinical characteristics. In some patients with asthma, aspirin and all nonsteroidal anti-inflammatory drugs (NSAIDs) trigger asthmatic attacks. This clinical syndrome is characterized by eosinophilic inflammation of nasal and bronchial tissue, often associated with nasal polyps. It has been reported that genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance. |
| カテゴリ | 免疫系疾患 |
| ネットワーク | - |
| 病因遺伝子 | TBX21 [HSA:30009] [KO:K10166] PTGER2 [HSA:5732] [KO:K04259] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | - |
| コメント | - |
| リンク | ICD-11: CA23.20 ICD-10: J45 MeSH: C565935 OMIM: 208550 |
| 文献 | PMID:15806396 著者 Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N, Shimizu M, Nakashima K, Cheng L, Doi S, Fujiwara H, Miyatake A, Fujita K, Higashi N, Taniguchi M, Enomoto T, Mao XQ, Nakashima H, Adra CN, Nakamura Y, Tamari M, Shirakawa T タイトル Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. 雑誌 Hum Genet 117:16-26 (2005) DOI:10.1007/s00439-005-1285-0 PMID:21370724 著者 Schaper C, Noga O, Koch B, Ewert R, Felix SB, Glaser S, Kunkel G, Gustavus B タイトル Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis. 雑誌 J Investig Allergol Clin Immunol 21:51-8 (2011) PMID:15496426 著者 Jinnai N, Sakagami T, Sekigawa T, Kakihara M, Nakajima T, Yoshida K, Goto S, Hasegawa T, Koshino T, Hasegawa Y, Inoue H, Suzuki N, Sano Y, Inoue I タイトル Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. 雑誌 Hum Mol Genet 13:3203-17 (2004) DOI:10.1093/hmg/ddh332 |