| H01328 | |
| H番号 | H01328 |
| 名称 | アスペルギルス症 |
| 概要 | Pulmonary aspergillus infections can be classified based on clinical syndromes into saprophytic infections, allergic disease and invasive disease. Invasive pulmonary aspergillosis, occurring in immunocompromised patients, reflects the most serious disease with a high case-fatality rate. Of the 185 recognized species of Aspergillus, 20 are known to cause infections in humans. Aspergillus fumigatus accounts for about 65 percent of all invasive infections in humans and is the mostly encountered species in pulmonary infections. Aspergillus flavus, Aspergillus niger, Aspergillus terreus and Aspergillus nidulans are less frequently causes of invasive and pulmonary infections. |
| カテゴリ | 真菌感染症 |
| ネットワーク | - |
| 病因遺伝子 | CLEC1A (susceptibility) [HSA:51267] [KO:K10069] CLEC7A (susceptibility) [HSA:64581] [KO:K10074] |
| 病原体 | Aspergillus fumigatus [GN:afm] Aspergillus flavus [GN:afv] Aspergillus clavatus [GN:act] |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | ボリコナゾール [DR:D00578] ポサコナゾール [DR:D02555] カスポファンギン酢酸塩 [DR:D02501] ミカファンギンナトリウム [DR:D02465] ミカファンギンナトリウム水和物 [DR:D11010] イサブコナゾニウム硫酸塩 [DR:D10643] フルシトシン [DR:D00323] |
| コメント | - |
| リンク | ICD-11: 1F20 ICD-10: B44 MeSH: D001228 MedlinePlus: 001326 OMIM: 614079 |
| 文献 | PMID:25135079 著者 Warris A タイトル The biology of pulmonary aspergillus infections. 雑誌 J Infect 69 Suppl 1:S36-41 (2014) DOI:10.1016/j.jinf.2014.07.011 PMID:29489751 (CLEC1A) 著者 Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, da Gloria Teixeira Sousa M, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, van de Veerdonk FL, Lacerda JF, Campos A, Carvalho A, Willment JA, Latge JP, Brown GD タイトル Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. 雑誌 Nature 555:382-386 (2018) DOI:10.1038/nature25974 PMID:22674328 (CLEC7A) 著者 Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DP, Brown GD, Underhill DM タイトル Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. 雑誌 Science 336:1314-7 (2012) DOI:10.1126/science.1221789 |