| H01359 | |
| H番号 | H01359 |
| 名称 | アナフィラキシー |
| 概要 | Anaphylaxis is a severe, life-threatening, systemic allergic reaction that is almost always unanticipated and may lead to death by airway obstruction or vascular collapse. Anaphylaxis can be triggered by a broad range of triggers. Food is the commonest trigger in children and drugs the commonest in adults. In addition to the environmental influences, studies suggest that a complex of genes affects the anaphylactic response. Anaphylaxis occurs as the result of an allergen response, usually immunoglobulin E-mediated, which leads to mast cell and basophil activation and a combination of dermatologic, respiratory, cardiovascular, gastrointestinal, and neurologic symptoms. |
| カテゴリ | 免疫系疾患 |
| ネットワーク | - |
| 病因遺伝子 | c-KIT (mutation) [HSA:3815] [KO:K05091] NLRP3 (polymorphism) [HSA:114548] [KO:K12800] IL-10 (polymorphism) [HSA:3586] [KO:K05443] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | デキサメタゾンリン酸エステルナトリウム [DR:D00975] ベタメタゾンリン酸エステルナトリウム [DR:D00972] アドレナリン [DR:D00095] ノルアドレナリン [DR:D00076] |
| コメント | - |
| リンク | ICD-11: 4A84 MeSH: D000707 |
| 文献 | PMID:20560905 著者 Ben-Shoshan M, Clarke AE タイトル Anaphylaxis: past, present and future. 雑誌 Allergy 66:1-14 (2011) DOI:10.1111/j.1398-9995.2010.02422.x PMID:22085665 著者 Arnold JJ, Williams PM タイトル Anaphylaxis: recognition and management. 雑誌 Am Fam Physician 84:1111-8 (2011) PMID:20236436 著者 Younker J, Soar J タイトル Recognition and treatment of anaphylaxis. 雑誌 Nurs Crit Care 15:94-8 (2010) DOI:10.1111/j.1478-5153.2010.00366.x PMID:20176258 著者 Simons FE タイトル Anaphylaxis. 雑誌 J Allergy Clin Immunol 125:S161-81 (2010) DOI:10.1016/j.jaci.2009.12.981 PMID:21682750 著者 Boden SR, Wesley Burks A タイトル Anaphylaxis: a history with emphasis on food allergy. 雑誌 Immunol Rev 242:247-57 (2011) DOI:10.1111/j.1600-065X.2011.01028.x |