| H01482 | |
| H番号 | H01482 |
| 名称 | 乳児血管腫 |
| 概要 | Infantile hemangiomas (IH) are neoplastic proliferations of vascular endothelial cells (ECs), characterized by a period of growth after birth, and eventual spontaneous involution. Forty percent of the lesions are associated with complications such as ulceration, bleeding, infection, pain, cardiac failure, airway compromise or eye impairment. Pathogenesis of IH is still shrouded in mystery even though various theories have been postulated to explain its origin. Recent studies provide strong evidence for the conclusion that the VEGF receptor 2 (VEGFR2) and Tumor Endothelial Marker 8 (TEM8) mutations represent risk factor mutations for hemangioma formation. In the proliferating phase, constitutive VEGFR2 signaling in ECs from hemangioma lesions affects downstream processes, including EC proliferation and migration, providing a mechanistic explanation for the rapid endothelial proliferation seen in hemangioma. |
| カテゴリ | 新生物 |
| ネットワーク | - |
| 病因遺伝子 | TEM8 [HSA:84168] [KO:K20909] VEGFR2 [HSA:3791] [KO:K05098] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | プロプラノロール塩酸塩 [DR:D00483] |
| コメント | - |
| リンク | ICD-11: 2E81.2Y ICD-10: D18.00 MeSH: D006391 OMIM: 602089 |
| 文献 | PMID:19190505 著者 Boye E, Jinnin M, Olsen BR タイトル Infantile hemangioma: challenges, new insights, and therapeutic promise. 雑誌 J Craniofac Surg 20 Suppl 1:678-84 (2009) DOI:10.1097/SCS.0b013e318193d6c1 PMID:19367160 著者 Boye E, Olsen BR タイトル Signaling mechanisms in infantile hemangioma. 雑誌 Curr Opin Hematol 16:202-8 (2009) DOI:10.1097/MOH.0b013e32832a07ff PMID:23668474 著者 Greenberger S, Bischoff J タイトル Pathogenesis of infantile haemangioma. 雑誌 Br J Dermatol 169:12-9 (2013) DOI:10.1111/bjd.12435 PMID:18931684 著者 Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E, Bischoff J, Vikkula M, Boye E, Olsen BR タイトル Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. 雑誌 Nat Med 14:1236-46 (2008) DOI:10.1038/nm.1877 PMID:17478771 著者 Drut R, Altamirano E タイトル Endothelial cells of intramuscular (infantile) hemangioma express glut1. 雑誌 Int J Surg Pathol 15:166-8 (2007) DOI:10.1177/1066896906299123 PMID:21039783 著者 Jinnin M, Ishihara T, Boye E, Olsen BR タイトル Recent progress in studies of infantile hemangioma. 雑誌 J Dermatol 37:939-55 (2010) DOI:10.1111/j.1346-8138.2010.00927.x PMID:20826985 著者 Mendiratta V, Jabeen M タイトル Infantile hemangioma: an update. 雑誌 Indian J Dermatol Venereol Leprol 76:469-75 (2010) DOI:10.4103/0378-6323.69048 PMID:23266916 著者 Chen TS, Eichenfield LF, Friedlander SF タイトル Infantile hemangiomas: an update on pathogenesis and therapy. 雑誌 Pediatrics 131:99-108 (2013) DOI:10.1542/peds.2012-1128 PMID:24906291 著者 Laranjo S, Costa G, Parames F, Freitas I, Martins JD, Trigo C, Pinto FF タイトル The role of propranolol in the treatment of infantile hemangioma. 雑誌 Rev Port Cardiol 33:289-95 (2014) DOI:10.1016/j.repc.2013.10.018 |