| H01646 | |
| H番号 | H01646 |
| 名称 | うつ病 |
| 概要 | Major depressive disorder (MDD) is the most common psychiatric disorder mainly characterized by depressed mood, loss of interest, feelings of worthlessness, and a high risk of suicide. Accumulated evidence suggests that both environmental and genetic factors are involved in the etiology of MDD although the pathogenesis of MDD remains unknown. Mutations in genes involved in brain serotonin synthesis, have been identified in patients. Brain serotonin deficiency has been hypothesized to play a role in a wide range of psychiatric diseases, including MDD. Several efficacious treatments for MDD are available, including different forms of psychotherapy and antidepressant medication. Recently, selective reuptake inhibitors (SSRIs, SNRIs,) have become the first-line antidepressant drug treatment of depression and replaced tricyclic antidepressants (TCA) and monoamine oxidase inhibitors (MAOI) due to fewer side-effects and ease of use. |
| カテゴリ | 精神及び行動の障害 |
| ネットワーク | nt06028(H01646) Dopamine and serotonin metabolism |
| 病因遺伝子 | TPH2 [HSA:121278] [KO:K00502] HTR2A [HSA:3356] [KO:K04157] FKBP5 [HSA:2289] [KO:K09571] |
| 病原体 | - |
| 環境要因 | - |
| 発癌物質 | - |
| 治療薬 | ジアゼパム [DR:D00293] クロルジアゼポキシド [DR:D00267] ブロマゼパム [DR:D01245] メタンフェタミン塩酸塩 [DR:D02242] レボメプロマジン塩酸塩 [DR:D01520] レボメプロマジンマレイン酸塩 [DR:D02248] イミプラミン塩酸塩 [DR:D00815] クロミプラミン塩酸塩 [DR:D00811] トリミプラミンマレイン酸塩 [DR:D02408] ロフェプラミン塩酸塩 [DR:D01285] スルピリド [DR:D01226] アリピプラゾール [DR:D01164] エチゾラム [DR:D01514] アミトリプチリン塩酸塩 [DR:D00809] ノルトリプチリン塩酸塩 [DR:D00816] ドスレピン塩酸塩 [DR:D01546] アモキサピン [DR:D00228] マプロチリン塩酸塩 [DR:D00818] パロキセチン塩酸塩水和物 [DR:D02260] セルトラリン塩酸塩 [DR:D00825] フルボキサミンマレイン酸塩 [DR:D00824] エスシタロプラムシュウ酸塩 [DR:D02567] トラゾドン塩酸塩 [DR:D00820] ベンラファキシン塩酸塩 [DR:D00821] 塩酸デュロキセチン [DR:D01179] ボルチオキセチン臭化水素酸塩 [DR:D10185] ペモリン [DR:D00744] セチプチリンマレイン酸塩 [DR:D02034] |
| コメント | - |
| リンク | ICD-11: 6A70 6A71 ICD-10: F32 F33 MeSH: D003863 OMIM: 608516 |
| 文献 | PMID:27497214 著者 Hou Z, Song X, Jiang W, Yue Y, Yin Y, Zhang Y, Liu Y, Yuan Y タイトル Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder. 雑誌 Psychiatry Res 255:1-8 (2016) DOI:10.1016/j.pscychresns.2016.07.011 PMID:25602134 著者 Sachs BD, Rodriguiz RM, Tran HL, Iyer A, Wetsel WC, Caron MG タイトル Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience. 雑誌 Psychoneuroendocrinology 53:69-81 (2015) DOI:10.1016/j.psyneuen.2014.12.019 PMID:26885016 著者 Lin CX, Hu Z, Yan ZM, Li W, Chen YS, Zhao JH, Zhang LQ, Zhao B, Zhong WT, Feng D タイトル Association between HTR2A T102C polymorphism and major depressive disorder: a meta-analysis in the Chinese population. 雑誌 Int J Clin Exp Med 8:20897-903 (2015) PMID:24856550 著者 Szczepankiewicz A, Leszczynska-Rodziewicz A, Pawlak J, Narozna B, Rajewska-Rager A, Wilkosc M, Zaremba D, Maciukiewicz M, Twarowska-Hauser J タイトル FKBP5 polymorphism is associated with major depression but not with bipolar disorder. 雑誌 J Affect Disord 164:33-7 (2014) DOI:10.1016/j.jad.2014.04.002 PMID:25159460 著者 Zhang Y, Becker T, Ma Y, Koesters M タイトル A systematic review of Chinese randomized clinical trials of SSRI treatment of depression. 雑誌 BMC Psychiatry 14:245 (2014) DOI:10.1186/s12888-014-0245-4 PMID:23737423 著者 Cuijpers P, Sijbrandij M, Koole SL, Andersson G, Beekman AT, Reynolds CF 3rd タイトル The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons. 雑誌 World Psychiatry 12:137-48 (2013) DOI:10.1002/wps.20038 PMID:26572745 著者 Bruno A, Morabito P, Spina E, Muscatello MR タイトル The Role of Levomilnacipran in the Management of Major Depressive Disorder: A Comprehensive Review. 雑誌 Curr Neuropharmacol 14:191-9 (2016) DOI:10.2174/1570159X14666151117122458 |