H00013 | |
H number | H00013 |
Name | Small cell lung cancer |
Description | Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control. |
Category | Cancer DIS_PATHWAY hsa05222 Small cell lung cancer |
Network | nt06267 Small cell lung cancer nt06512(H00013) Chromosome cohesion and segregation nt06524(H00013) Apoptosis |
Gene | MYC (amplification) [HSA:4609] [KO:K04377] BCL2 (overexpression) [HSA:596] [KO:K02161] FHIT [HSA:2272] [KO:K01522] TP53 [HSA:7157] [KO:K04451] RB1 [HSA:5925] [KO:K06618] PTEN [HSA:5728] [KO:K01110] PPP2R1B [HSA:5519] [KO:K03456] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | Methotrexate sodium [DR:D02115] Etoposide [DR:D00125] Etoposide phosphate [DR:D04107] Topotecan hydrochloride [DR:D02168] Nivolumab [DR:D10316] Durvalumab [DR:D10808] Atezolizumab [DR:D10773] Lurbinectedin [DR:D11644] Trilaciclib dihydrochloride [DR:D11987] |
Comment | - |
Other DBs | ICD-11: 2C25.1 ICD-10: C34 MeSH: D055752 |
Reference | PMID:12741677 AUTHORS Yokota J, Nishioka M, Tani M, Kohno T. TITLE Genetic alterations responsible for metastatic phenotypes of lung cancer cells. JOURNAL Clin Exp Metastasis 20:189-93 (2003) DOI:10.1023/a:1022978932215 PMID:12711111 AUTHORS Sanchez-Cespedes M. TITLE Dissecting the genetic alterations involved in lung carcinogenesis. JOURNAL Lung Cancer 40:111-21 (2003) DOI:10.1016/S0169-5002(03)00033-3 PMID:12407699 AUTHORS Mitsuuchi Y, Testa JR. TITLE Cytogenetics and molecular genetics of lung cancer. JOURNAL Am J Med Genet 115:183-8 (2002) DOI:10.1002/ajmg.10692 PMID:16112428 AUTHORS Panani AD, Roussos C. TITLE Cytogenetic and molecular aspects of lung cancer. JOURNAL Cancer Lett 239:1-9 (2006) DOI:10.1016/j.canlet.2005.06.030 PMID:2983887 (MYC amplification) AUTHORS Saksela K, Bergh J, Lehto VP, Nilsson K, Alitalo K TITLE Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer. JOURNAL Cancer Res 45:1823-7 (1985) PMID:17426248 (BCL2 overexpression) AUTHORS Olejniczak ET, Van Sant C, Anderson MG, Wang G, Tahir SK, Sauter G, Lesniewski R, Semizarov D TITLE Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains. JOURNAL Mol Cancer Res 5:331-9 (2007) DOI:10.1158/1541-7786.MCR-06-0367 PMID:8620533 (FHIT) AUTHORS Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K, Croce CM TITLE The FHIT gene 3p14.2 is abnormal in lung cancer. JOURNAL Cell 85:17-26 (1996) DOI:10.1016/s0092-8674(00)81078-8 PMID:2554494 (TP53) AUTHORS Takahashi T, Nau MM, Chiba I, Birrer MJ, Rosenberg RK, Vinocour M, Levitt M, Pass H, Gazdar AF, Minna JD TITLE p53: a frequent target for genetic abnormalities in lung cancer. JOURNAL Science 246:491-4 (1989) DOI:10.1126/science.2554494 PMID:2594029 (RB1) AUTHORS Yandell DW, Campbell TA, Dayton SH, Petersen R, Walton D, Little JB, McConkie-Rosell A, Buckley EG, Dryja TP TITLE Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. JOURNAL N Engl J Med 321:1689-95 (1989) DOI:10.1056/NEJM198912213212501 PMID:9696041 (PTEN) AUTHORS Yokomizo A, Tindall DJ, Drabkin H, Gemmill R, Franklin W, Yang P, Sugio K, Smith DI, Liu W TITLE PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. JOURNAL Oncogene 17:475-9 (1998) DOI:10.1038/sj.onc.1201956 PMID:9765152 (PPP2R1B) AUTHORS Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J, Evans GA TITLE Alterations of the PPP2R1B gene in human lung and colon cancer. JOURNAL Science 282:284-7 (1998) DOI:10.1126/science.282.5387.284 |