H00041 | |
H number | H00041 |
Name | Kaposi sarcoma |
Description | Kaposi sarcoma (KS) is an angioproliferative disease classified into classic KS, endemic KS, iatrogenic KS, and HIV-associated KS (HIV-KS), however, they share the same histological traits and are all associated with infection by the human herpesvirus 8 (HHV8; also known as KSHV). Evidence indicates that KS progression occurs upon the deregulated expression of anti-apoptotic genes (Bcl-2), oncogenes (c-myc, c-int, ras) and oncosuppressor genes (TP53), and is associated with the long-lasting expression of HHV8 latency genes (LANA, v-cyc D, v-FLIP, Kaposin). All these genes are, in fact, expressed or altered in most KS spindle cells in the nodular-late stage of KS. Bcl-2 acts as a major KS progression factor, and TP53 and c-myc may also have a role in disease progression. HHV8 latency gene products may be involved in KS progression due to their capability of promoting cell growth by direct effects or antiapoptotic effects. |
Category | Cancer; Viral infectious disease DIS_PATHWAY hsa05167 Kaposi sarcoma-associated herpesvirus infection |
Network | nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06505(H00041) WNT signaling nt06513(H00041) Complement cascade nt06516(H00041) TNF signaling nt06517(H00041) TLR signaling nt06518(H00041) JAK-STAT signaling nt06524(H00041) Apoptosis nt06526(H00041) MAPK signaling nt06528(H00041) Calcium signaling nt06530(H00041) PI3K signaling |
Gene | BCL2 (overexpression) [HSA:596] [KO:K02161] MYC (overexpression) [HSA:4609] [KO:K04377] FGF3 (overexpression, mutation) [HSA:2248] [KO:K04358] KRAS (overexpression, mutation) [HSA:3845] [KO:K07827] TP53 [HSA:7157] [KO:K04451] |
Pathogen | Human herpesvirus 8 (KSHV) [GN:T40081] Human immunodeficiency virus 1 [GN:T40001] |
Env factor | - |
Carcinogen | - |
Drug | Alitretinoin [DR:D02815] Vinblastine sulfate [DR:D01068] Paclitaxel [DR:D00491] Doxorubicin hydrochloride [DR:D01275] Interferon alfa-2b [DR:D02745] |
Comment | - |
Other DBs | ICD-11: 2B57 ICD-10: C46 MeSH: D012514 |
Reference | PMID:11423257 (GENE) AUTHORS Ensoli B, Sgadari C, Barillari G, Sirianni MC, Sturzl M, Monini P TITLE Biology of Kaposi's sarcoma. JOURNAL Eur J Cancer 37:1251-69 (2001) DOI:10.1016/S0959-8049(01)00121-6 PMID:15334644 AUTHORS Schwartz RA. TITLE Kaposi's sarcoma: an update. JOURNAL J Surg Oncol 87:146-51 (2004) DOI:10.1002/jso.20090 |