H01674 | |
H number | H01674 |
Name | Ankylosing spondylitis; Bechterew disease |
Description | Ankylosing spondylitis (AS), formerly also known as Bechterew's disease, is a rheumatic disease of the axial skeleton that mainly affects the spine and the sacroiliac joint in the pelvis. AS is one of a group of inflammatory diseases, called spondyloarthritides, which share features. This disease is characterized by erosion, sclerosis, and ossification, which may result in complete fusion and rigidity of the spine. Regarding extra-articular manifestations, the most frequent is anterior uveitis. The major functional losses occur during the first 10 years of disease. It usually begins in the second or third decade of life, preferentially in HLA-B27-positive Caucasian males. Its etiology and pathogenesis are not completely understood, but the most prevalent hypothesis involves immune mediation as its major mechanism, including several cytokines. To date, more than 40 genetic variants have been identified that influence the risk of developing AS, including HLA alleles such as HLA-B27. |
Category | Musculoskeletal disease |
Network | - |
Gene | HLA-B [HSA:3106] [KO:K06751] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | Triamcinolone acetonide [DR:D00983] Dexamethasone [DR:D00292] Dexamethasone sodium phosphate [DR:D00975] Hydrocortisone [DR:D00088] Hydrocortisone sodium succinate [DR:D00978] Prednisolone [DR:D00472] Prednisolone sodium phosphate [DR:D00981] Prednisone [DR:D00473] Indomethacin [DR:D00141] Methylprednisolone [DR:D00407] Methylprednisolone sodium succinate [DR:D00751] Methylprednisolone acetate [DR:D00979] Naproxen [DR:D00118] Naproxen sodium [DR:D00970] Corticotropin [DR:D00146] Cortisone acetate [DR:D00973] Celecoxib [DR:D00567] Tofacitinib citrate [DR:D09783] Upadacitinib hydrate [DR:D11048] Etanercept [DR:D00742] Infliximab [DR:D02598] Adalimumab [DR:D02597] Certolizumab pegol [DR:D03441] Golimumab [DR:D04358] Secukinumab [DR:D09967] Naproxen and esomeprazole magnesium [DR:D11576] Meclofenamate sodium [DR:D00169] |
Comment | See also H00630 Rheumatoid arthritis and H01656 Psoriasis. |
Other DBs | ICD-11: FA92 ICD-10: M45 MeSH: D013167 OMIM: 106300 |
Reference | PMID:23090374 AUTHORS Gouveia EB, Elmann D, Morales MS TITLE Ankylosing spondylitis and uveitis: overview. JOURNAL Rev Bras Reumatol 52:742-56 (2012) DOI:10.1590/S0482-50042012000500009 PMID:27445458 AUTHORS Koenders MI, van den Berg WB TITLE Secukinumab for rheumatology: development and its potential place in therapy. JOURNAL Drug Des Devel Ther 10:2069-80 (2016) DOI:10.2147/DDDT.S105263 PMID:26439405 AUTHORS Brown MA, Kenna T, Wordsworth BP TITLE Genetics of ankylosing spondylitis--insights into pathogenesis. JOURNAL Nat Rev Rheumatol 12:81-91 (2016) DOI:10.1038/nrrheum.2015.133 |