D00896 | |
D number | D00896 |
Classification | Drug |
Name | Efavirenz (JAN/INN); Sustiva (TN) |
Component | - |
Formula | C14H9ClF3NO2 |
Exact mass | 315.0274 |
Mol weight | 315.675 |
Structural formula | ![]() |
Sequence | - |
Sequence type | - |
Source | - |
Upper DGroup | Antiviral DG01656 HIV reverse transcriptase inhibitor Antineoplastic DG01889 Non-nucleoside reverse transcriptase inhibitor Cyp substrate DG01633 CYP3A substrate Cyp inhibitor DG01933 CYP2C19 inhibitor Cyp inducer DG01635 CYP3A4 inducer DG01897 CYP3A5 inducer |
Remark | Same as: C08088 Therapeutic category: 6250 ATC code: J05AG03 |
Activity | - |
Disease | - |
Comment | Non-nucleoside reverse transcriptase inhibitor (NNRTI) |
Target | RNA-directed DNA polymerase |
Metabolism | Enzyme: CYP3A4 [HSA:1576], CYP2B6 [HSA:1555] |
Interaction | CYP induction: CYP2B6 [HSA:1555], CYP3A [HSA:1576 1577 1551] CYP inhibition: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576] Transporter inhibition: ABCC2 [HSA:1244], ABCC3 [HSA:8714] |
Other DBs | CAS: 154598-52-4 PubChem: 7847960 ChEBI: 119486 ChEMBL: CHEMBL223228 DrugBank: DB00625 PDB-CCD: EFZ LigandBox: D00896 NIKKAJI: J727.577C |
KCF data | - |