| D00896 | |
| D number | D00896 |
| Classification | Drug |
| Name | Efavirenz (JAN/INN); Sustiva (TN) |
| Component | - |
| Formula | C14H9ClF3NO2 |
| Exact mass | 315.0274 |
| Mol weight | 315.675 |
| Structural formula |  |
| Sequence | - |
| Sequence type | - |
| Source | - |
| Upper DGroup | Antiviral DG01656 HIV reverse transcriptase inhibitor Antineoplastic DG01889 Non-nucleoside reverse transcriptase inhibitor Cyp substrate DG01633 CYP3A substrate Cyp inhibitor DG01933 CYP2C19 inhibitor Cyp inducer DG01635 CYP3A4 inducer DG01897 CYP3A5 inducer |
| Remark | Same as: C08088 Therapeutic category: 6250 ATC code: J05AG03 |
| Activity | - |
| Disease | - |
| Comment | Non-nucleoside reverse transcriptase inhibitor (NNRTI) |
| Target | RNA-directed DNA polymerase |
| Metabolism | Enzyme: CYP3A4 [HSA:1576], CYP2B6 [HSA:1555] |
| Interaction | CYP induction: CYP2B6 [HSA:1555], CYP3A [HSA:1576 1577 1551] CYP inhibition: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576] Transporter inhibition: ABCC2 [HSA:1244], ABCC3 [HSA:8714] |
| Other DBs | CAS: 154598-52-4 PubChem: 7847960 ChEBI: 119486 ChEMBL: CHEMBL223228 DrugBank: DB00625 PDB-CCD: EFZ LigandBox: D00896 NIKKAJI: J727.577C |
| KCF data | - |