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Life science projects in Japan

Former name: Genome, post genome projects in Japan

List of projects | Life Science Databases(LSDB)

Genome Network Project
Project Name Genome Network Project
Start Year 2004
End Year 2008
Implementing Period -
Budget Amount 3.0 billion yen (requested in FY2004)
2.3 billion yen (FY2005)
2.3 billion yen (FY2006)
2.3 billion yen (FY2007)
1.5 billion yen (FY2008)
Major Researchers Genome Network Project Action Group, Chairman: Yoshiyuki Sakaki (RIKEN)
(Analysis of Genome Functional Information)
- Yoshihide Hayashizaki (RIKEN Omics Science Center) and 6 other researchers
(Establishment of the Human Genome Network Platform)
- Takashi Gojobori (National Institute of Genetics) and 3 other researchers
(Development of Genome Analysis Technologies for the Next Generation)
- Takashi Ito (University of Tokyo Graduate School of Frontier Sciences) and 4 other researchers
(Analysis of Individual Biological Functions)
- 19 researchers in total
(Development of Analytical Technologies for Dynamic Network)
- Hiroaki Kitano (Systems Biology Institute) and 2 other researchers
Summary Comprehensive analysis concerning gene expression regulatory functions
Major Features of Project *Analysis of Genome Functional Information
- Focused Analysis of Genome Functional Information - CAGE Tag Sequencing of Human and Mouse cDNAs (RIKEN)
- Elucidation of Interactions between Transcription Factors and Discovery and Identification of Cofactors by Yeast Two-Hybrid Method (Hitachi, Ltd.)
- Elucidation of Human Transcription Regulome with Genome Tiling Arrays (Tokyo Institute of Technology)
- Large-Scale Analysis of Transcription Factor Complexes by In Vitro Virus Method (Keio University)
- Construction of Human Genome-Wide Retroviral siRNA Library (University of Tokyo)
- Establishment of Human cDNA Clones for Genome Network Analysis (University of Tokyo)
- Understanding of Genome Network by Analysis of Transcription Factor Complexes with Antibodies (Kazusa DNA Research Institute)
(Establishment of the Human Genome Network Platform)
- Construction of Human Genome Network Platform (Construction of public DB, National Institute of Genetics)
*Analysis of Individual Biological Functions
- 19 research themes in total
(Development of Genome Analysis Technologies for the Next Generation)
- 5 research themes in total
(Development of Analytical Technologies for Dynamic Network)
- 3 research themes in total
Description of Project Excerpts from "Purpose and Summary of the Project( http://genomenetwork.nig.ac.jp/mext-life/genome/project.html , Japanese)"
Once the decoding of the human genome was completed in 2003, the Ministry of Education, Culture, Sports, Science and Technology (MEXT) started the Genome Network Project in 2004.

Genes are believed to operate by mutually adjusting each gene functions in order to exhibit biological phenomena rather than function independently.
The aim of the Genome Network Project is to elucidate such complex interactions between human genomes - that is to say, the network of human genes. Once this human genome network has been revealed, we will be able to utilize the information for the further development of human life sciences and new treatments for diseases.

To achieve this aim, the Project is carried out through collaboration between a number of organizations, each responsible for one of the following tasks: 1) investigating the network structure, 2) systematically summarizing findings and providing them to related research bodies, 3) developing new gene analysis technologies, 4) elucidating further biological phenomena by analyzing their networks, and 5) developing analytical technologies for the dynamic networks...
List of Research Theme Overviews ( http://genomenetwork.nig.ac.jp/mext-life/project/index.html , Japanese)
Public Release Status - The policy is to first release data to consortium members and then to the public promptly after securing intellectual property rights and publishing scientific papers. The period for privileged access by consortium members will be worked out by the Genome Network Project Action Group (Article 12 - Public Release of Research Outcomes, Rules of the Genome Network Consortium).
- "Genome Network Platform/5 Basic Items/Public Release" states that "any data that has been released to consortium members for more than 6 months are made widely available to the public."
Classification of Database Public Release Status Partially shared
Public Database Genome Network Platform Integrated Database( http://genomenetwork.nig.ac.jp/index_e.html )
Data Download Site -
Website Genome Network Project ( http://genomenetwork.nig.ac.jp/mext-life/index.html )(Japanese)
Implementing Ministry/Agency Ministry of Education, Culture, Sports, Science and Technology (MEXT)
Reports -
Evaluation Reports - 44th Meeting of Expert Panel on Evaluation, Council for Science and Technology Policy: About "Genome Network Project" (All files are written in Japanese.)
- http://www8.cao.go.jp/cstp/output/iken031125_2.pdf
- http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-1-1.pdf
- http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-1-2.pdf
- http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-2-1.pdf
- http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-2-2.pdf
- http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-2-3.pdf

- 45th Meeting of Expert Panel on Evaluation, Council for Science and Technology Policy: About the evaluation result of "Genome Network Project" conducted in FY2003(
http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu45/siryo2-1.pdf ,Japanese)

- Agenda of (48th Meeting of) Expert Panel on Evaluation, Council for Science and Technology Policy ( http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu48/haihu-si48.html ,Japanese)
All files are written in Japanese.
- Evaluation of Nationally-Important Research and Development Projects Implemented by Council for Science and Technology Policy (Council for Science and Technology Policy on November 25, 2003) About "Genome Network Research" ( http://www8.cao.go.jp/cstp/output/iken031125_2.pdf )
- Reference 1-2 ( http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-1-2.pdf )
- Reference 2-1 ( http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-2-1.pdf )
- Reference 2-2 ( http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-2-2.pdf )
- Reference 2-3 ( http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-2-3.pdf )
- Reference 1 Strategic Promotion of Genome Network Research (September 16, 2003) ( http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu29/siryo3-1-1.pdf )

- Overview of Strategic Promotion of Genome Network Research (Genome Network Project) (May 19, 2005) ( http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu45/siryo2-2.pdf ,Japanese)

- Results of Follow-Up Evaluation of New Large-Scale Research and Development (August 4, 2005, Council for Science and Technology Policy) ( http://www8.cao.go.jp/cstp/tyousakai/hyouka/H17follow.pdf ,Japanese)

- Agenda of (82th Meeting of) Expert Panel on Evaluation, Council for Science and Technology Policy (Links to evaluation reports are contained.)( http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu82/haihu-si82.html ,Japanese)

- 83th Meeting of Expert Panel on Evaluation, Council for Science and Technology Policy: The result of "Genome Network Project" examination panel(
http://www8.cao.go.jp/cstp/tyousakai/hyouka/haihu83/siryo2.pdf ,Japanese)
Other Literatures - Protein, Nucleic Acid and Enzyme Vol.49 No.17, Special Genome Network Issue. (in Japanese)
(Click here for the top page/back issues of regular and extra issues of Protein, Nucleic Acid and Enzyme/2004 Genome Network.) ( http://www.kyoritsu-pub.co.jp/pne/ )
- Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet., 38, 626-635 (2006) ( http://www.ncbi.nlm.nih.gov/pubmed/16645617 )