monrd0022
Medals oligonucleic drug ID monrd0022
ATC Classification -
Product Name ISIS EIF4E Rx
Synonims eIF-4E Antisense Oligonucleotide
Country US
Company Ionis Pharmaceuticals
phase Ib/II
Type Antisense
Adaptation Diseases Castrate-Resistant Prostate Cancer
Target Molecule eIF-4E
Remarks ISIS EIF4E Rx is an antisense drug designed to bind eukaryotic translation initiation factor 4E (eIF4E) , which is a powerful cancer gene including colorectal carcinogenesis (CRC), and inhibit the production of eIF4E protein.
In a phase I / II study conducted on patients with irinotecan refractory colorectal cancer, the peripheral blood concentration of eIF4E mRNA decreased in 13 of 19 cases.
Nucleic Acid Sequence -
Source https://www.clinicaltrialsregister.eu/ctr-search/trial/2010-022239-12/HU,
https://www.clinicaltrialsregister.eu/ctr-search/trial/2010-022240-21/HU,
https://www.ncbi.nlm.nih.gov/pubmed/27194579
DrugBank -
TargetProtein - UniProt P06730
TargetProtein - PDB 4TPW