Medals oligonucleic drug ID monrd0025
ATC Classification C10AX11
Product Name Mipomersen
Synonims Mipomersen Sodium
Country US
Company Ionis Pharmaceuticals
Genzyme Corporation and its Affiliates
Genzyme Europe B.V.
Hospital of the University of Munich
phase AD
Type Antisense
Adaptation Diseases Hypercholesterolemia
Target Molecule apolipoprotein B mRNA
Remarks Mipomersen is used to treat homozygotes of patients with hypercholesterolemia and familial hypercholesterolemia.
This can be administered systemically.
Nucleic Acid Sequence 5'-mG-mC*-mC*-mU*-mC*-dA-dG-dT-dC*-dT-dG-dC*-dT-dT-dC*-mG-mC*-mA-mC*-mC*-3'
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DrugBank DB05528
TargetProtein - UniProt P04114
TargetProtein - PDB 5K81, 5K82, 5K83