FBA1 | |
Project ID | FBA1 [Protein] |
Project Theme | Structural and functional studies of bacterial type Ⅲ and type Ⅳ protein export systems |
Project Theme (short) | Bacterial protein export systems |
Principal Investigator | Katsumi Imada |
Affiliation | Department of Macromolecular Science, Graduate School of Science, Osaka University |
Backgrounds | - Pathogenic bacteria secret effector proteins to infect host organisms - Their secretion systems are composed of multiple protein complexes - Structural and functional characterization of the secretion systems could lead to developments of unique anti-infective agents |
Highlights | - The energy source of the protein export in the type III secretion system has been elucidated - Five major proteins for the type IV secretion system have been identified - Several structures of t component proteins for the type III and IV secretion systems have been determined |
Outline | In pathogenic bacteria, the secretion system (protein export apparatus) is used to secrete effector proteins that help the bacteria infect multicellular, eukaryotic organisms. The proteins are secreted directly from the bacterial cell into the cells of the organism to be infected (the host). Type III secretion is homologous to bacterial flagellar basal body. It is like a molecular syringe through which a bacterium (e.g. certain types of Salmonella, Shigella) can inject proteins into eukaryotic cells. Legionella pneumophila, the causing agent of legionellosis (Legionnaires' disease) utilizes type IV secretion system. Our goal in this project is to elucidate the molecular mechanisms by which these secretion systems recognize and export effector proteins and the energies for the export are supplied. Judicious inhibition of the functions of these secretion systems could lead to developments of unique anti-infective agents for infectious diseases. |
Review | Curr. Opin. Struct. Biol. Mol Biosyst |
CSML File | FBA1.csml |