| FEA6 | |
| Project ID |  FEA6 [Protein] |
| Project Theme | Study on chemical biology of the deacetylase SIRT3 involved in the regulation of an energy metabolism |
| Project Theme (short) | Metabolism regulatory deacetylase |
| Principal Investigator | Akihiro Ito |
| Affiliation | Advanced Science Institute, RIKEN |
| Backgrounds | - Sirtuin family enzymes are histone deacetylases and human has 7 Sirtuins (SIRT1-7) - SIRT3 located in the mitochondrial matrix regulates the activities of several enzymes involved in energy metabolism - Compounds SIRT3 that regulate the activities of SIRT3 could provide insights in therapeutics developments for metabolic syndrome |
| Highlights | - We have developed screening systems for SIRT3 activities and identified a variety of candidate inhibitors - Elucidation of the biological functions of SIRT3 in the regulation of energy metabolism is in progress using mouse models |
| Outline | Acetylation and deacetylation of a histone are important posttranslational modifications in the nuclei. Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an N-acetyl lysine amino acid on a histone. Eighteen subtypes of HDACs are known in human. Class III HDACs are called Sirtuin or Sir2 proteins and are found in organisms ranging from bacteria to humans. Sirtuins have been implicated in influencing aging and regulating transcription, apoptosis and stress resistance. Humans possess seven Sirtuins (SIRT1-7). We have focused on SIRT3 that is a soluble protein located in the mitochondrial matrix and found that SIRT3 regulates the activities of several enzymes involved in energy metabolism, suggesting its link with aging. In this project, we will develop reagents that regulate the activities of SIRT3 to reveal its physiology, especially biological functions of SIRT3 in the regulation of energy metabolism. |
| Review | - |
| CSML File | FEA6.csml |