| FBA4 | |
| Project ID |  FBA4 [Protein] |
| Project Theme | Structural biology of transcription factors and histone modification factors |
| Project Theme (short) | Chromatin & transcription |
| Principal Investigator | Yoshifumi Nishimura |
| Affiliation | International Graduate School of Arts and Sciences, Yokohama City University |
| Backgrounds | - A variety of proteins are involved in gene transcription - These proteins comprise a complex molecular network - We will study the network with emphasis on structures to elucidate the mechanism of gene transcription |
| Highlights | - Structures of general transcription factors complex TFIIE-TFIIH have been determined - Structures of complexes and binding domains of other transcription factors have been solved |
| Outline | Chromatin is the combination of DNA and proteins that makes up chromosomes. The major components of chromatin are DNA and histone proteins, which package and order the DNA into structural units called nucleosomes. The functions of chromatin are to package DNA into a smaller volume to fit in the cell and to serve as a mechanism to control expression and DNA replication. Histone proteins are modified by various post-translational modification to alter DNA packing. Acetylation results in the loosening of chromatin and lends itself to replication and transcription. When certain residues are methylated they hold DNA together strongly and restrict access to various enzymes. We will solve structures of general transcription factors, activating transcription factors, histone modification factors and related proteins to elucidate the mechanism of gene transcription. |
| Review | - |
| CSML File | FBA4.csml |