FBA6 | |
Project ID | FBA6 [Protein] |
Project Theme | Structure-function analysis of protein complexes that regulate vesicular traffic |
Project Theme (short) | Vesicular traffic proteins |
Principal Investigator | Soichi Wakatsuki |
Affiliation | Institute of Materials Structure Science, High Energy Accelerator Research Organization(KEK) |
Backgrounds | - Cells possess vesicular trafficking pathways for materials transport - Proteins involved in the vesicular trafficking comprise a complex molecular network - Structural and functional analyses will be pursued to understand the molecular network |
Highlights | - Structures of several protein complexes in the vesicular trafficking have been determined - Both the selection of target proteins for the structural analyses guided by the functional information and the functional analyses based on the solved structures were found to be effective - Functional analyses of plant-specific RAB GTPase(ARA6)and SNARE(VAMP727) revealed that these proteins act cooperatively in the plant- unique endosomal trafficking network |
Outline | Within a cell, there are various organelles (membrane-enclosed compartments) that have specific functions and are usually separately enclosed within its own lipid bilayers. These compartments are in constant communication, with molecules being passed from a donor compartment to a target compartment by means of numerous membrane-enclosed transport packages. Some of these packages are small spherical vesicles, while others are larger irregular vesicles or fragments of the donor compartment. Vesicles continually bud off from one membrane and fuse with another, carrying membrane components and soluble molecules referred to as cargo. This membrane traffic flows along highly organized, directional routes. In this project, we will characterize protein complexes involved in the regulatory vesicular traffic in terms of functions and structures. |
Review | Annu. Rev. Cell Dev. Biol. Curr. Opin. Cell Biol. |
CSML File | FBA6.csml |