| H00311 | |
| H number | H00311 |
| Name | Legionellosis; Legionnaires disease |
| Description | Legionnaires disease (LD), caused by Gram-negative Legionella spp., can be nosocomial, community acquired or travel related. L. pneumophila is the most common cause of LD. The source of LD is potable water systems that become colonized by the microorganism, transmitted by inhalation of contaminated aerosols and aspiration. Classically, it can cause two different forms of disease in humans: LD, with an incubation period of 2-10 days, which is a multisystem illness that involves the lungs, causing pneumonia, and can cause neurological symptoms, diarrhea and high mortality (up to 50%), and Pontiac fever, with a shorter incubation period of 1-2 days, which is an acute, self-limited, influenza-like disease that does not cause pneumonia. Patients who are at risk for infection include the immunosuppressed, especially those submitted to transplantation (mainly of solid organs), those with chronic lung disease, smokers, and the elderly. |
| Category | Bacterial infectious disease DIS_PATHWAY hsa05134 Legionellosis |
| Network | nt06517(H00311) TLR signaling |
| Gene | TLR5 [HSA:7100] [KO:K10168] |
| Pathogen | Legionella pneumophila [GN:lpn lpf lpp lpc lpa lpe] Legionella longbeachae [GN:llo] Legionella sainthelensi [GN:lsh] pore-forming toxin [KO:K11022] |
| Env factor | - |
| Carcinogen | - |
| Drug | Erythromycin [DR:D00140] Erythromycin ethylsuccinate [DR:D01361] Erythromycin lactobionate [DR:D02009] Erythromycin stearate [DR:D02184] |
| Comment | - |
| Other DBs | ICD-11: 1C19 ICD-10: A48.1 A48.2 MeSH: D007876 D007877 MedlinePlus: 000616 OMIM: 608556 |
| Reference | PMID:20051846 AUTHORS Carratala J, Garcia-Vidal C TITLE An update on Legionella. JOURNAL Curr Opin Infect Dis 23:152-7 (2010) DOI:10.1097/QCO.0b013e328336835b PMID:19622057 AUTHORS Levin AS TITLE Nosocomial legionellosis: prevention and management. JOURNAL Expert Rev Anti Infect Ther 7:57-68 (2009) DOI:10.1586/14787210.7.1.57 PMID:14623910 (TLR5) AUTHORS Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A TITLE A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. JOURNAL J Exp Med 198:1563-72 (2003) DOI:10.1084/jem.20031220 |