| H00320 | |
| H number | H00320 |
| Name | Helicobacter pylori infection |
| Description | Helicobacter pylori (HP) is a gram-negative pathogenic bacterium that specifically colonizes in the gastric epithelium and causes chronic gastritis, peptic ulcer disease, and/or gastric malignancies. Persistent infection can cause inflammation and gastritis that may lead to carcinogenesis. Transmission is still not entirely clarified, but human-to-human spread through oral-oral or fecal-oral route is thought to be the most plausible. The prevalence of HP infection varies between different geographical regions; generally, the prevalence is about 30% in developed and up to 80% in developing countries. Although HP may sometimes be eradicated by antibiotics given for other infections, infection usually persists life-long unless specific combination antibiotic therapy is taken. |
| Category | Bacterial infectious disease DIS_PATHWAY hsa05120 Epithelial cell signaling in Helicobacter pylori infection |
| Network | - |
| Gene | - |
| Pathogen | Helicobacter pylori [GN:hpy hpj hpa hps hpg hpp hpb hpl hpi hpq hpw hef hpf heq hex hpv hey hpya hpyk hpyb hpyc hpyd hpye hpyf hpyg hpyh hpyj heb hez] |
| Env factor | - |
| Carcinogen | - |
| Drug | Omeprazole magnesium [DR:D05259] Lansoprazole [DR:D00355] Rabeprazole sodium [DR:D00724] Esomeprazole magnesium [DR:D01984] Esomeprazole magnesium dihydrate [DR:D11114] Omeprazole, clarithromycin and amoxicillin [DR:D10246] Amoxicillin hydrate, clarithromycin and lansoprazole [DR:D08774] Bismuth subcitrate, tetracycline and metronidazole [DR:D10245] Vonoprazan, amoxicillin and clarithromycin [DR:D10775] Omeprazole magnesium, amoxicillin and rifabutin [DR:D11858] Amoxicillin [DR:D00229] Clarithromycin [DR:D00276] |
| Comment | - |
| Other DBs | ICD-11: DA51.0 DA60.1 DA62.1 DA63.1 ICD-10: A49.8 MeSH: D016481 |
| Reference | PMID:21546717 AUTHORS Albaker WI TITLE Helicobacter pylori infection and its relationship to metabolic syndrome: is it a myth or fact? JOURNAL Saudi J Gastroenterol 17:165-9 (2011) DOI:10.4103/1319-3767.80377 PMID:21896079 AUTHORS Goh KL, Chan WK, Shiota S, Yamaoka Y TITLE Epidemiology of Helicobacter pylori infection and public health implications. JOURNAL Helicobacter 16 Suppl 1:1-9 (2011) DOI:10.1111/j.1523-5378.2011.00874.x PMID:17309745 AUTHORS Kabir S TITLE The current status of Helicobacter pylori vaccines: a review. JOURNAL Helicobacter 12:89-102 (2007) DOI:10.1111/j.1523-5378.2007.00478.x PMID:14501997 AUTHORS Moss SF, Sood S TITLE Helicobacter pylori. JOURNAL Curr Opin Infect Dis 16:445-51 (2003) DOI:10.1097/01.qco.0000092816.64370.e2 |