H00330 | |
H number | H00330 |
Name | Methicillin-resistant Staphylococcal aureus (MRSA) infection |
Description | Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major multidrug-resistant bacteria which have become endemic in the hospital environment, particularly in intensive care units (ICUs). Originally limited to the hospital setting, MRSA is a growing cause of infections in the community. Community-associated MRSA (CA-MRSA) strains are genetically different from MRSA strains originating in the hospital. Its increase in the community is of concern because CA-MRSA strains appear to be highly virulent, and colonization with CA-MRSA is often undetected in hospitalized patients, which can facilitate its potential for becoming resistant to multiple antibiotics. Health care-associated MRSA (HA-MRSA) is usually associated with pneumonia, urinary tract, blood stream, and surgical wound infections. In contrast, CA-MRSA strains are overwhelmingly associated with skin and soft tissue infections. |
Category | Bacterial infectious disease DIS_PATHWAY hsa05150 Staphylococcus aureus infection |
Network | - |
Gene | - |
Pathogen | Staphylococcus aureus [GN:sau sav saw sah sar sac suk sut sux suw sug sauz saut sauj sauk sauq sauv sauw saux sauy saum saur] (hospital-acquired MRSA) Staphylococcus aureus [GN:sam sax saa suu suj suz saun sauu saug] (community-acquired MRSA) |
Env factor | - |
Carcinogen | - |
Drug | Vancomycin hydrochloride [DR:D00926] Mupirocin calcium [DR:D02195] |
Comment | - |
Other DBs | ICD-11: MG51.00 ICD-10: U82.1 MeSH: D013203 MedlinePlus: 007261 |
Reference | PMID:20825344 AUTHORS Otto M TITLE Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. JOURNAL Annu Rev Microbiol 64:143-62 (2010) DOI:10.1146/annurev.micro.112408.134309 PMID:18996277 AUTHORS Chavez TT, Decker CF TITLE Health care-associated MRSA versus community-associated MRSA. JOURNAL Dis Mon 54:763-8 (2008) DOI:10.1016/j.disamonth.2008.09.004 PMID:16813982 AUTHORS Henderson DK TITLE Managing methicillin-resistant staphylococci: a paradigm for preventing nosocomial transmission of resistant organisms. JOURNAL Am J Infect Control 34:S46-54: discussion S64-73 (2006) DOI:10.1016/j.ajic.2006.05.228 |