| H00333 | |
| H number | H00333 |
| Name | Streptococcal infection |
| Description | Streptococci are gram-positive bacteria. Among the beta-hemolytic streptococci, Streptococcus pyogenes (Group A streptococci, GAS) and Streptococcus agalactiae (Group B streptococci, GBS) are major human pathogens. GAS causes over 600 million cases of infections each year, ranging from mild pharyngitis to severe streptococcal toxic shock-like syndrome (STSS), and GBS causes neonatal invasive infections including sepsis, pneumonia, and meningitis. |
| Category | Bacterial infectious disease |
| Network | - |
| Gene | - |
| Pathogen | Streptococcus pyogenes [GN:spy spz spym spya spm spg sps sph spi spj spk spf spa spb stg stx soz stz spyh spyo] Streptococcus agalactiae [GN:sag san sak sagt sagn sagj] pore-forming toxin [KO:K11031 K11045 K11046] pore-forming toxin [KO:K11052] superantigen [KO:K11040] ADP-ribosyltransferase SpyA [KO:K11044] |
| Env factor | - |
| Carcinogen | - |
| Drug | Clindamycin phosphate [DR:D01073] Clindamycin palmitate hydrochloride [DR:D01990] Clindamycin hydrochloride [DR:D02132] |
| Comment | - |
| Other DBs | ICD-11: 1B51 1B53 CA40.07 ICD-10: A40 A49.1 G00.2 J02.0 J03.0 J15.3 J15.4 M60.0A P36.0 P36.1 MeSH: D013290 |
| Reference | PMID:21921933 AUTHORS Cole JN, Barnett TC, Nizet V, Walker MJ TITLE Molecular insight into invasive group A streptococcal disease. JOURNAL Nat Rev Microbiol 9:724-36 (2011) DOI:10.1038/nrmicro2648 PMID:21415743 AUTHORS Lynskey NN, Lawrenson RA, Sriskandan S TITLE New understandings in Streptococcus pyogenes. JOURNAL Curr Opin Infect Dis 24:196-202 (2011) DOI:10.1097/QCO.0b013e3283458f7e PMID:21672083 AUTHORS Melin P TITLE Neonatal group B streptococcal disease: from pathogenesis to preventive strategies. JOURNAL Clin Microbiol Infect 17:1294-303 (2011) DOI:10.1111/j.1469-0691.2011.03576.x |