| H00334 | |
| H number | H00334 |
| Name | Bacterial endocarditis; Infective endocarditis |
| Description | Infective endocarditis is a microbial infection of the endocardial surface of the heart. The characteristic lesion, a vegetation, is composed of a collection of platelets, fibrin, microorganisms, and inflammatory cells. It most commonly involves heart valves but may also occur at the site of a septal defect, on the chordae tendineae, or on the mural endocardium. Staphylococci and streptococci account for 80% of cases of infective endocarditis, with staphylococci currently the most common pathogens. Cerebral complications are the most frequent and most severe extracardiac complications. |
| Category | Bacterial infectious disease |
| Network | - |
| Gene | - |
| Pathogen | Streptococcus viridans Streptococcus sanguinis [GN:ssa] Streptococcus suis [GN:ssu ssv] Streptococcus gordonii [GN:sgo] Staphylococcus aureus [GN:sah saj sug] Enterococcus Corynebacterium diphtheriae [GN:cdt cde cdr cda] Rothia aeria [GN:raj] Aggregatibacter aphrophilus [GN:aap] Aggregatibacter actinomycetemcomitans [GN:aat aao aan] Mammaliicoccus lentus [GN:mlen] Legionella cardiaca [GN:lcad] Cardiobacterium hominis Eikenella corrodens Kingella kingae superantigen [KO:K11040 K11041 K11042 K11043] pore-forming toxin [KO:K11031 K11032 K11038 K11039] membrane-damaging toxin [KO:K01114] |
| Env factor | - |
| Carcinogen | - |
| Drug | Metronidazole [DR:D00409] Streptomycin sulfate [DR:D01350] Vancomycin hydrochloride [DR:D00926] Gentamicin sulfate [DR:D01063] Erythromycin lactobionate [DR:D02009] Ampicillin sodium [DR:D02119] Penicillin G potassium [DR:D01053] Penicillin G procaine [DR:D02461] Penicillin G sodium [DR:D05408] Cefazolin sodium [DR:D00905] Imipenem and cilastatin sodium [DR:D00344] Daptomycin [DR:D01080] |
| Comment | - |
| Other DBs | ICD-11: BC0Z ICD-10: I39.8 MeSH: D004697 MedlinePlus: 000681 |
| Reference | PMID:16902214 AUTHORS Beynon RP, Bahl VK, Prendergast BD TITLE Infective endocarditis. JOURNAL BMJ 333:334-9 (2006) DOI:10.1136/bmj.333.7563.334 PMID:23574121 AUTHORS Hoen B, Duval X TITLE Clinical practice. Infective endocarditis. JOURNAL N Engl J Med 368:1425-33 (2013) DOI:10.1056/NEJMcp1206782 PMID:11794152 AUTHORS Mylonakis E, Calderwood SB TITLE Infective endocarditis in adults. JOURNAL N Engl J Med 345:1318-30 (2001) DOI:10.1056/NEJMra010082 |