| H00339 | |
| H number | H00339 |
| Name | Botulism |
| Description | Botulism is an acute neuroparalytic illness caused by a botulinum toxin produced by Clostridium botulinum, an anaerobic, gram-positive bacterium. Botulism occurs in four forms: foodborne, wound, infant botulism, and adult intestinal toxemia. Botulinum toxin blocks acetylcholine release in a dose-dependent fashion, resulting in symmetrical, descending, and progressive muscle weakness. Delay in treatment may allow progression of paralysis. |
| Category | Bacterial infectious disease |
| Network | - |
| Gene | - |
| Pathogen | Clostridium botulinum [GN:cbo cba cbh cby cbl cbb cbi cbt cbf cbm cbj] Clostridium butyricum Clostridium baratii botulinum neurotoxin (BoNT) [KO:K06011] hyaluronidase/collagenase [KO:K01387 K08587] pore-forming toxin [KO:K06442 K11068] |
| Env factor | - |
| Carcinogen | - |
| Drug | Penicillin G potassium [DR:D01053] Penicillin G sodium [DR:D05408] |
| Comment | - |
| Other DBs | ICD-11: 1A11 ICD-10: A05.1 MeSH: D001906 MedlinePlus: 000598 |
| Reference | PMID:21171845 AUTHORS Zhang JC, Sun L, Nie QH TITLE Botulism, where are we now? JOURNAL Clin Toxicol (Phila) 48:867-79 (2010) DOI:10.3109/15563650.2010.535003 PMID:18388640 AUTHORS Dembek ZF, Smith LA, Rusnak JM TITLE Botulism: cause, effects, diagnosis, clinical and laboratory identification, and treatment modalities. JOURNAL Disaster Med Public Health Prep 1:122-34 (2007) DOI:10.1097/DMP.0b013e318158c5fd PMID:17224901 AUTHORS Brook I TITLE Botulism: the challenge of diagnosis and treatment. JOURNAL Rev Neurol Dis 3:182-9 (2006) PMID:21412916 AUTHORS Chalk C, Benstead TJ, Keezer M TITLE Medical treatment for botulism. JOURNAL Cochrane Database Syst Rev CD008123 (2011) DOI:10.1002/14651858.CD008123.pub2 PMID:12503947 AUTHORS Robinson RF, Nahata MC TITLE Management of botulism. JOURNAL Ann Pharmacother 37:127-31 (2003) DOI:10.1345/aph.1C034 |