| H00342 | |
| H number | H00342 |
| Name | Tuberculosis |
| Description | Tuberculosis is an infectious disease caused by strains of mycobacteria, mainly Mycobacterium tuberculosis, resulting in an estimated two million deaths each year worldwide, more than from any other single bacterial pathogen. Inhalation is the predominant pathway of infection, making pulmonary tuberculosis the most common form of tuberculosis. Tuberculosis may arise either from a recent infection with M. tuberculosis, or from the reactivation of dormant bacilli, years or decades after initial infection. Extrapulmonary tuberculosis mainly results from reactivation of a tuberculous focus after hematogenous dissemination or lymphogenous spread from a primary, usually pulmonary focus. |
| Category | Bacterial infectious disease DIS_PATHWAY hsa05152 Tuberculosis |
| Network | nt06517(H00342) TLR signaling |
| Gene | IFNG (protection) [HSA:3458] [KO:K04687] IFNGR1 (susceptibility/protection) [HSA:3459] [KO:K05132] IFNGR2 [HSA:3460] [KO:K05133] HLA-DRB1 (susceptibility) [HSA:3123] [KO:K06752] HLA-DQB1 (susceptibility) [HSA:3119] [KO:K06752] SLC11A1 (susceptibility) [HSA:6556] [KO:K12347] VDR (susceptibility) [HSA:7421] [KO:K08539] MBL2 (protection) [HSA:4153] [KO:K03991] CCL2 (susceptibility) [HSA:6347] [KO:K14624] CD209 (susceptibility) [HSA:30835] [KO:K06563] CISH (susceptibility) [HSA:1154] [KO:K04701] IRGM (protection) [HSA:345611] [KO:K14139] SP110 (susceptibility) [HSA:3431] [KO:K24503] TIRAP (protection) [HSA:114609] [KO:K05403] TLR2 (susceptibility) [HSA:7097] [KO:K10159] |
| Pathogen | Mycobacterium tuberculosis [GN:mtu mtc mtf mtb mtk mtg mti mte mtl mto mtd mtj mtuc mtue mtuh maf] Mycobacterium canettii [GN:mce mcq mcv mcx mcz] |
| Env factor | - |
| Carcinogen | - |
| Drug | Triamcinolone acetonide [DR:D00983] Dexamethasone [DR:D00292] Dexamethasone sodium phosphate [DR:D00975] Hydrocortisone [DR:D00088] Hydrocortisone sodium succinate [DR:D00978] Prednisolone [DR:D00472] Prednisolone sodium phosphate [DR:D00981] Streptomycin sulfate [DR:D01350] Prednisone [DR:D00473] Methylprednisolone [DR:D00407] Methylprednisolone acetate [DR:D00979] Cortisone acetate [DR:D00973] Aminosalicylic acid [DR:D00162] Cycloserine [DR:D00877] Rifampin [DR:D00211] Rifapentine [DR:D00879] Capreomycin sulfate [DR:D00135] Isoniazid [DR:D00346] Rifampin and isoniazid [DR:D11578] Ethionamide [DR:D00591] Pyrazinamide [DR:D00144] Ethambutol hydrochloride [DR:D00878] Rifampin, isoniazid and pyrazinamide [DR:D10210] BCG vaccine [DR:D03063] Freeze-dried BCG vaccine (for percutaneous use) [DR:D06466] |
| Comment | - |
| Other DBs | ICD-11: 1B10 1B11 1B12 ICD-10: A15 A16 A17 A18 A19 MeSH: D014376 MedlinePlus: 000077 OMIM: 607948 |
| Reference | PMID:20206579 AUTHORS Moller M, Hoal EG TITLE Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. JOURNAL Tuberculosis (Edinb) 90:71-83 (2010) DOI:10.1016/j.tube.2010.02.002 PMID:17147011 AUTHORS De Backer AI, Mortele KJ, De Keulenaer BL, Parizel PM TITLE Tuberculosis: epidemiology, manifestations, and the value of medical imaging in diagnosis. JOURNAL JBR-BTR 89:243-50 (2006) PMID:21420161 AUTHORS Lawn SD, Zumla AI TITLE Tuberculosis. JOURNAL Lancet 378:57-72 (2011) DOI:10.1016/S0140-6736(10)62173-3 PMID:16690980 (IFNG IFNGR1 IFNGR2) AUTHORS Cooke GS, Campbell SJ, Sillah J, Gustafson P, Bah B, Sirugo G, Bennett S, McAdam KP, Sow O, Lienhardt C, Hill AV TITLE Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis. JOURNAL Am J Respir Crit Care Med 174:339-43 (2006) DOI:10.1164/rccm.200601-088OC PMID:24024195 (SLC11A1 VDR HLA-DRB1 HLA-DQB1) AUTHORS Wu F, Zhang W, Zhang L, Wu J, Li C, Meng X, Wang X, He P, Zhang J TITLE NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis among the Chinese Kazakh population: a case-control study. JOURNAL Biomed Res Int 2013:484535 (2013) DOI:10.1155/2013/484535 PMID:16103355 (SLC11A1) AUTHORS Malik S, Abel L, Tooker H, Poon A, Simkin L, Girard M, Adams GJ, Starke JR, Smith KC, Graviss EA, Musser JM, Schurr E TITLE Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. JOURNAL Proc Natl Acad Sci U S A 102:12183-8 (2005) DOI:10.1073/pnas.0503368102 PMID:32847384 (VDR) AUTHORS Maruthai K, Sankar S, Subramanian M TITLE Methylation Status of VDR Gene and its Association with Vitamin D Status and VDR Gene Expression in Pediatric Tuberculosis Disease. JOURNAL Immunol Invest 51:73-87 (2022) DOI:10.1080/08820139.2020.1810702 PMID:33270011 (MBL2) AUTHORS Taheri M, Karimloo R, Sarani H, Molashahi B, Naderi M, Bahari G, Hashemi M TITLE Association Study of MBL2 Gene Polymorphisms and Risk of Tuberculosis in Southeast of Iran. JOURNAL Prague Med Rep 121:236-243 (2020) DOI:10.14712/23362936.2020.20 PMID:20041183 (CCL2) AUTHORS Hasan Z, Cliff JM, Dockrell HM, Jamil B, Irfan M, Ashraf M, Hussain R TITLE CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis. JOURNAL PLoS One 4:e8459 (2009) DOI:10.1371/journal.pone.0008459 PMID:16379498 (CD209) AUTHORS Barreiro LB, Neyrolles O, Babb CL, Tailleux L, Quach H, McElreavey K, Helden PD, Hoal EG, Gicquel B, Quintana-Murci L TITLE Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. JOURNAL PLoS Med 3:e20 (2006) DOI:10.1371/journal.pmed.0030020 PMID:28954234 (CISH) AUTHORS Queval CJ, Song OR, Carralot JP, Saliou JM, Bongiovanni A, Deloison G, Deboosere N, Jouny S, Iantomasi R, Delorme V, Debrie AS, Park SJ, Gouveia JC, Tomavo S, Brosch R, Yoshimura A, Yeramian E, Brodin P TITLE Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. JOURNAL Cell Rep 20:3188-3198 (2017) DOI:10.1016/j.celrep.2017.08.101 PMID:19750224 (IRGM) AUTHORS Intemann CD, Thye T, Niemann S, Browne EN, Amanua Chinbuah M, Enimil A, Gyapong J, Osei I, Owusu-Dabo E, Helm S, Rusch-Gerdes S, Horstmann RD, Meyer CG TITLE Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains. JOURNAL PLoS Pathog 5:e1000577 (2009) DOI:10.1371/journal.ppat.1000577 PMID:17149599 (SP110) AUTHORS Szeszko JS, Healy B, Stevens H, Balabanova Y, Drobniewski F, Todd JA, Nejentsev S TITLE Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. JOURNAL Hum Genet 121:155-60 (2007) DOI:10.1007/s00439-006-0293-z PMID:18305471 (TIRAP) AUTHORS Nejentsev S, Thye T, Szeszko JS, Stevens H, Balabanova Y, Chinbuah AM, Hibberd M, van de Vosse E, Alisjahbana B, van Crevel R, Ottenhoff TH, Png E, Drobniewski F, Todd JA, Seielstad M, Horstmann RD TITLE Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations. JOURNAL Nat Genet 40:261-2; author reply 262-3 (2008) DOI:10.1038/ng0308-261 PMID:14979495 (TLR2) AUTHORS Ogus AC, Yoldas B, Ozdemir T, Uguz A, Olcen S, Keser I, Coskun M, Cilli A, Yegin O TITLE The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. JOURNAL Eur Respir J 23:219-23 (2004) DOI:10.1183/09031936.03.00061703 |