| H00370 | |
| H number | H00370 |
| Name | Progressive multifocal leukoencephalopathy |
| Description | Progressive multifocal leukoencephalopathy (PML) is a fatal neurological disorder characterized by destruction of oligodendrocytes by the JC polyomavirus that occurs in immunosuppressed individuals such as patients with AIDS. Patients with PML show white matter lesions on head computed tomography scan or magnetic resonance imaging. |
| Category | Viral infectious disease |
| Network | - |
| Gene | - |
| Pathogen | JC polyomavirus [GN:T40072] |
| Env factor | - |
| Carcinogen | - |
| Drug | - |
| Comment | Combination therapy AIDS-associated: Highly active antiretroviral therapy (HAART) + Cidofovir Immunodepressed patient: Discontinuation of immunosuppressive agent + Cidofovir [DR:D00273] |
| Other DBs | ICD-11: 8A45.02 ICD-10: A81.2 MeSH: D007968 MedlinePlus: 000674 |
| Reference | PMID:15167073 AUTHORS Koralnik IJ TITLE New insights into progressive multifocal leukoencephalopathy. JOURNAL Curr Opin Neurol 17:365-70 (2004) DOI:10.1097/00019052-200406000-00019 PMID:7551117 AUTHORS Major EO, Ault GS TITLE Progressive multifocal leukoencephalopathy: clinical and laboratory observations on a viral induced demyelinating disease in the immunodeficient patient. JOURNAL Curr Opin Neurol 8:184-90 (1995) |