| H01045 | |
| H number | H01045 |
| Name | Schistosomiasis |
| Description | Schistosomiasis is a parasitic disease caused by trematode worms of the genus Schistosoma. Schistosomiasis is one of the most devastating tropical diseases in the world, and WHO estimates 600 million people at risk of infection with 200 million infected. Among nonimmune patients, host's immune response to schistosome eggs leads to acute schistosomiasis that is characterized by cercarial dermatitis and Katayama fever. Life-threatening cardiac and neurological complications may occur. Schistosome eggs can also lead to chronic fibrotic response in host tissues, causing gastrointestinal and liver diseases. |
| Category | Parasitic infectious disease |
| Network | - |
| Gene | - |
| Pathogen | Schistosoma mansoni [GN:smm] Schistosoma haematobium [GN:shx] Schistosoma japonicum |
| Env factor | - |
| Carcinogen | - |
| Drug | Praziquantel [DR:D00471] |
| Comment | - |
| Other DBs | ICD-11: 1F86 ICD-10: B65 MeSH: D012552 |
| Reference | PMID:19292768 AUTHORS Burke ML, Jones MK, Gobert GN, Li YS, Ellis MK, McManus DP TITLE Immunopathogenesis of human schistosomiasis. JOURNAL Parasite Immunol 31:163-76 (2009) DOI:10.1111/j.1365-3024.2009.01098.x PMID:17160074 AUTHORS Wilson MS, Mentink-Kane MM, Pesce JT, Ramalingam TR, Thompson R, Wynn TA TITLE Immunopathology of schistosomiasis. JOURNAL Immunol Cell Biol 85:148-54 (2007) DOI:10.1038/sj.icb.7100014 PMID:20222897 AUTHORS Jaureguiberry S, Paris L, Caumes E TITLE Acute schistosomiasis, a diagnostic and therapeutic challenge. JOURNAL Clin Microbiol Infect 16:225-31 (2010) DOI:10.1111/j.1469-0691.2009.03131.x |