H01436 | |
H number | H01436 |
Name | Guillain-Barre syndrome |
Description | Guillain-Barre syndrome (GBS) is an acute polyneuropathy characterized by progressive motor weakness of limbs with areflexia. This disease is usually triggered by an infection, which provokes immune-mediated nerve dysfunction. GBS can be subdivided into the classic acute demyelinating type, acute motor axonal neuropathy (AMAN), and acute motor and sensory axonal neuropathy (AMSAN). Classic acute demyelinating type is designated acute inflammatory demyelinating polyneuropathy (AIDP), representing the great majority of cases in Europe and North America. A mutation in the PMP22 gene was identified in a family with AIDP. AMAN is the most prevalent form in China. The incidence of AMSAN is very low. The axonal forms of GBS are caused by certain autoimmune mechanisms, due to a molecular mimicry between antecedent bacterial infection (particularly Campylobacter jejuni) and human peripheral nerve gangliosides. |
Category | Nervous system disease |
Network | - |
Gene | PMP22 [HSA:5376] [KO:K19289] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | - |
Comment | - |
Other DBs | ICD-11: 8C01.0 ICD-10: G61.0 MeSH: D020275 OMIM: 139393 |
Reference | PMID:12439896 AUTHORS Korn-Lubetzki I, Argov Z, Raas-Rothschild A, Wirguin I, Steiner I TITLE Family with inflammatory demyelinating polyneuropathy and the HNPP 17p12 deletion. JOURNAL Am J Med Genet 113:275-8 (2002) DOI:10.1002/ajmg.10725 PMID:15958124 AUTHORS van Doorn PA TITLE Treatment of Guillain-Barre syndrome and CIDP. JOURNAL J Peripher Nerv Syst 10:113-27 (2005) DOI:10.1111/j.1085-9489.2005.0010203.x PMID:25738052 AUTHORS Kumar M, Aroor S, Mundkur S, Kumar S TITLE Guillain-barre syndrome: a clinical study of twenty children. JOURNAL J Clin Diagn Res 9:SC09-12 (2015) DOI:10.7860/JCDR/2015/8344.5491 PMID:16271648 AUTHORS Hughes RA, Cornblath DR TITLE Guillain-Barre syndrome. JOURNAL Lancet 366:1653-66 (2005) DOI:10.1016/S0140-6736(05)67665-9 PMID:22850724 AUTHORS Yuki N TITLE Guillain-Barre syndrome and anti-ganglioside antibodies: a clinician-scientist's journey. JOURNAL Proc Jpn Acad Ser B Phys Biol Sci 88:299-326 (2012) DOI:10.2183/pjab.88.299 |