H01473 | |
H number | H01473 |
Name | Erythema nodosum leprosum |
Description | Reactional states of leprosy are expressions of immunological disturbance and are generally divided into two variants: type 1 (Jopling's type I or reversal reaction) and type 2 (Jopling's type II reaction). Erythema Nodosum Leprosum (ENL), the main symptom of a type-2 reaction in leprosy, is caused by a humoral immune response to Mycobacterium leprae. Patients with ENL become acutely sick with fever, malaise, and crops of painful erythematous nodules. Inflammation often affects other systems causing iritis, neuritis, myositis, lymphadenitis, arthritis, dactylitis, and orchitis. |
Category | Bacterial infectious disease |
Network | - |
Gene | - |
Pathogen | Mycobacterium leprae [GN:mle mlb] |
Env factor | - |
Carcinogen | - |
Drug | Thalidomide [DR:D00754] |
Comment | See also H00344 Leprosy. |
Other DBs | ICD-11: 1B20.21 EB31 ICD-10: A30.8 L52 MeSH: D004893 |
Reference | PMID:16687695 AUTHORS Pocaterra L, Jain S, Reddy R, Muzaffarullah S, Torres O, Suneetha S, Lockwood DN TITLE Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India. JOURNAL Am J Trop Med Hyg 74:868-79 (2006) DOI:10.4269/ajtmh.2006.74.868 PMID:24098819 AUTHORS Voorend CG, Post EB TITLE A systematic review on the epidemiological data of erythema nodosum leprosum, a type 2 leprosy reaction. JOURNAL PLoS Negl Trop Dis 7:e2440 (2013) DOI:10.1371/journal.pntd.0002440 PMID:23000940 AUTHORS Travassos AR, Antunes J, Pacheco D, Almeida LS, Filipe P, Marques MS TITLE Erythema nodosum leprosum associated with minocycline. JOURNAL Acta Dermatovenerol Alp Pannonica Adriat 21:39-41 (2012) DOI:10.2478/v10162-012-0011-6 |