| H01500 | |
| H number | H01500 |
| Name | Lupus nephritis |
| Description | Lupus nephritis is a severe organ manifestation of systemic lupus erythematosus (SLE) that can affect up to 70% of the SLE population. In childhood SLE, nephritis is present in up to 90% of the cases. This disease is one of the most serious complications of SLE, with a high morbidity and mortality. Clinical manifestations of active lupus nephritis include proteinuria, active urinary sediments, and progressive renal dysfunction. It is initiated by the deposition of immunoglobulins and formation of immune complexes in the glomerular and tubulo-interstitial compartments of the kidney. There is emerging evidence that the interaction between anti-dsDNA antibodies and kidney cells, notably mesangial cells, proximal renal tubular epithelial cells, and glomerular endothelial cells plays a significant role in disease pathogenesis. |
| Category | Immune system disease |
| Network | - |
| Gene | - |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Voclosporin [DR:D09033] |
| Comment | See also H00080 Systemic lupus erythematosus. Lupus nephritis is staged according to the classification revised by the International Society of Nephrology (ISN) and the Renal Pathology Society (RPS) in 2003. |
| Other DBs | ICD-11: 4A40.0Y ICD-10: M32.1 N08.5 MeSH: D008181 OMIM: 607965 607966 607967 |
| Reference | PMID:14747370 AUTHORS Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M TITLE The classification of glomerulonephritis in systemic lupus erythematosus revisited. JOURNAL J Am Soc Nephrol 15:241-50 (2004) DOI:10.1097/01.ASN.0000108969.21691.5D PMID:22761629 AUTHORS Yung S, Chan TM TITLE Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis: getting to know the unknown. JOURNAL Clin Dev Immunol 2012:139365 (2012) DOI:10.1155/2012/139365 PMID:12215904 AUTHORS Quintero-Del-Rio AI, Kelly JA, Kilpatrick J, James JA, Harley JB TITLE The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3). JOURNAL Genes Immun 3 Suppl 1:S57-62 (2002) DOI:10.1038/sj.gene.6363901 PMID:22570338 AUTHORS Wang S, Li X, Qu L, Wang R, Chen Y, Li Q, He X, Zhang X, Wang H, Wu J, Xu Y, Chen J TITLE Tacrolimus versus cyclophosphamide as treatment for diffuse proliferative or membranous lupus nephritis: a non-randomized prospective cohort study. JOURNAL Lupus 21:1025-35 (2012) DOI:10.1177/0961203312448105 PMID:19479701 AUTHORS Pons-Estel GJ, Alarcon GS, McGwin G Jr, Danila MI, Zhang J, Bastian HM, Reveille JD, Vila LM TITLE Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. JOURNAL Arthritis Rheum 61:830-9 (2009) DOI:10.1002/art.24538 |