| H01565 | |
| H number | H01565 |
| Name | Wernicke encephalopathy; Wernicke-Korsakoff syndrome |
| Description | Wernicke encephalopathy is a rare but serious neurological pathology due to a vitamin B1 deficiency. It is commonly associated with heavy alcohol consumption. Other clinical associations are with hyperemesis gravidarum, starvation, and prolonged intravenous feeding. Most patients present with the triad of ophthalmoplegia, ataxia, and confusion. It can be associated with life-threatening complication like central pontine myelinolysis. When Wernicke encephalopathy is suspected, treatment with high-dose parenteral thiamine (vitamin B1) should be given. If it is not treated promptly or if treatment is inadequate it can lead to death or to the chronic memory disorder, Korsakoff syndrome. Recent studies have suggested that an association exists between Wernicke encephalopathy and genetic polymorphisms in the thiamine transporter (SLC19A2). |
| Category | Endocrine and metabolic disease |
| Network | - |
| Gene | SLC19A2 [HSA:10560] [KO:K14610] |
| Pathogen | - |
| Env factor | - |
| Carcinogen | - |
| Drug | Thiamine hydrochloride [DR:D02094] |
| Comment | - |
| Other DBs | ICD-11: 5B5A.10 ICD-10: E51.2 MeSH: D014899 OMIM: 277730 |
| Reference | PMID:26004883 AUTHORS Yahia M, Najeh H, Zied H, Khalaf M, Salah AM, Sofienne BM, Laidi B, Hamed J, Hayenne M TITLE Wernicke's encephalopathy: A rare complication of hyperemesis gravidarum. JOURNAL Anaesth Crit Care Pain Med 34:173-7 (2015) DOI:10.1016/j.accpm.2014.09.005 PMID:24701066 AUTHORS Kantor S, Prakash S, Chandwani J, Gokhale A, Sarma K, Albahrani MJ TITLE Wernicke's encephalopathy following hyperemesis gravidarum. JOURNAL Indian J Crit Care Med 18:164-6 (2014) DOI:10.4103/0972-5229.128706 PMID:16015585 AUTHORS Guerrini I, Thomson AD, Cook CC, McQuillin A, Sharma V, Kopelman M, Reynolds G, Jauhar P, Harper C, Gurling HM TITLE Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS). JOURNAL Am J Med Genet B Neuropsychiatr Genet 137B:17-9 (2005) DOI:10.1002/ajmg.b.30194 PMID:19151162 AUTHORS Kopelman MD, Thomson AD, Guerrini I, Marshall EJ TITLE The Korsakoff syndrome: clinical aspects, psychology and treatment. JOURNAL Alcohol Alcohol 44:148-54 (2009) DOI:10.1093/alcalc/agn118 |