H01646 | |
H number | H01646 |
Name | Major depressive disorder |
Description | Major depressive disorder (MDD) is the most common psychiatric disorder mainly characterized by depressed mood, loss of interest, feelings of worthlessness, and a high risk of suicide. Accumulated evidence suggests that both environmental and genetic factors are involved in the etiology of MDD although the pathogenesis of MDD remains unknown. Mutations in genes involved in brain serotonin synthesis, have been identified in patients. Brain serotonin deficiency has been hypothesized to play a role in a wide range of psychiatric diseases, including MDD. Several efficacious treatments for MDD are available, including different forms of psychotherapy and antidepressant medication. Recently, selective reuptake inhibitors (SSRIs, SNRIs,) have become the first-line antidepressant drug treatment of depression and replaced tricyclic antidepressants (TCA) and monoamine oxidase inhibitors (MAOI) due to fewer side-effects and ease of use. |
Category | Mental and behavioural disorder |
Network | nt06028(H01646) Dopamine and serotonin metabolism |
Gene | TPH2 [HSA:121278] [KO:K00502] HTR2A [HSA:3356] [KO:K04157] FKBP5 [HSA:2289] [KO:K09571] |
Pathogen | - |
Env factor | - |
Carcinogen | - |
Drug | Selegiline [DR:D03731] Aripiprazole [DR:D01164] Brexpiprazole [DR:D10309] Desipramine hydrochloride [DR:D00812] Imipramine hydrochloride [DR:D00815] Imipramine pamoate [DR:D08071] Trimipramine maleate [DR:D02408] Amitriptyline hydrochloride [DR:D00809] Nortriptyline hydrochloride [DR:D00816] Protriptyline hydrochloride [DR:D00484] Amoxapine [DR:D00228] Maprotiline hydrochloride [DR:D00818] Fluoxetine hydrochloride [DR:D00823] Citalopram hydrobromide [DR:D00822] Paroxetine hydrochloride hemihydrate [DR:D02260] Paroxetine hydrochloride [DR:D05374] Paroxetine mesylate [DR:D05375] Sertraline hydrochloride [DR:D00825] Escitalopram oxalate [DR:D02567] Isocarboxazid [DR:D02580] Tranylcypromine sulfate [DR:D00826] Trazodone hydrochloride [DR:D00820] Nefazodone hydrochloride [DR:D00819] Mirtazapine [DR:D00563] Bupropion hydrochloride [DR:D00817] Bupropion hydrobromide [DR:D07938] Venlafaxine hydrochloride [DR:D00821] Venlafaxine besylate monohydrate [DR:D12403] Duloxetine hydrochloride [DR:D01179] Desvenlafaxine [DR:D07793] Desvenlafaxine succinate [DR:D02570] Desvenlafaxine succinate anhydrous [DR:D11619] Vilazodone hydrochloride [DR:D09699] Vortioxetine hydrobromide [DR:D10185] Levomilnacipran hydrochloride [DR:D10133] Perphenazine and amitriptyline hydrochloride [DR:D10294] Olanzapine and fluoxetine hydrochloride [DR:D10206] Dextromethorphan hydrobromide and bupropion hydrochloride [DR:D12493] |
Comment | - |
Other DBs | ICD-11: 6A70 6A71 ICD-10: F32 F33 MeSH: D003863 OMIM: 608516 |
Reference | PMID:27497214 AUTHORS Hou Z, Song X, Jiang W, Yue Y, Yin Y, Zhang Y, Liu Y, Yuan Y TITLE Prognostic value of imbalanced interhemispheric functional coordination in early therapeutic efficacy in major depressive disorder. JOURNAL Psychiatry Res 255:1-8 (2016) DOI:10.1016/j.pscychresns.2016.07.011 PMID:25602134 AUTHORS Sachs BD, Rodriguiz RM, Tran HL, Iyer A, Wetsel WC, Caron MG TITLE Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience. JOURNAL Psychoneuroendocrinology 53:69-81 (2015) DOI:10.1016/j.psyneuen.2014.12.019 PMID:26885016 AUTHORS Lin CX, Hu Z, Yan ZM, Li W, Chen YS, Zhao JH, Zhang LQ, Zhao B, Zhong WT, Feng D TITLE Association between HTR2A T102C polymorphism and major depressive disorder: a meta-analysis in the Chinese population. JOURNAL Int J Clin Exp Med 8:20897-903 (2015) PMID:24856550 AUTHORS Szczepankiewicz A, Leszczynska-Rodziewicz A, Pawlak J, Narozna B, Rajewska-Rager A, Wilkosc M, Zaremba D, Maciukiewicz M, Twarowska-Hauser J TITLE FKBP5 polymorphism is associated with major depression but not with bipolar disorder. JOURNAL J Affect Disord 164:33-7 (2014) DOI:10.1016/j.jad.2014.04.002 PMID:25159460 AUTHORS Zhang Y, Becker T, Ma Y, Koesters M TITLE A systematic review of Chinese randomized clinical trials of SSRI treatment of depression. JOURNAL BMC Psychiatry 14:245 (2014) DOI:10.1186/s12888-014-0245-4 PMID:23737423 AUTHORS Cuijpers P, Sijbrandij M, Koole SL, Andersson G, Beekman AT, Reynolds CF 3rd TITLE The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons. JOURNAL World Psychiatry 12:137-48 (2013) DOI:10.1002/wps.20038 PMID:26572745 AUTHORS Bruno A, Morabito P, Spina E, Muscatello MR TITLE The Role of Levomilnacipran in the Management of Major Depressive Disorder: A Comprehensive Review. JOURNAL Curr Neuropharmacol 14:191-9 (2016) DOI:10.2174/1570159X14666151117122458 |